Histopathologic study of the Molteno glaucoma implant in three patients.
Histopathologic study of the Molteno glaucoma implant in three patients.
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DOI：
10.1016/s0002-9394(14)77017-5
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发表时间：
1990-10
影响因子：
4.2
通讯作者：
B. Rubin;C. Chan;M. Burnier;L. Munion;J. Freedman
中科院分区：
文献类型：
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作者：
B. Rubin;C. Chan;M. Burnier;L. Munion;J. Freedman
植入莫尔特诺青光眼植入物的三只眼睛（一只眼睛上皮向下生长，一只眼睛虹膜角膜内皮综合征，一只眼睛无晶状体眼和青光眼）在植入后2 - 6年摘除。组织学检查显示，没有证据表明青光眼植入装置对眼睛的巩膜或结膜造成侵蚀。在滤过泡壁的外层中，存在很少且大多数退化的炎性细胞，这代表最小的炎性反应。对这3例患者的输卵管进行扫描电子显微镜检查，结果显示输卵管完整、通畅且无降解迹象。进入前房的导管没有引起明显的炎症，即使向下生长的上皮细胞排列在前房中，导管也保持通畅。莫尔特诺接骨板很少或没有引起炎症反应。因此，莫尔特诺青光眼植入物是青光眼手术后高失败风险患者的有用器械。
Three eyes with the Molteno glaucoma implant (one eye with epithelial downgrowth, one eye with iridocorneal endothelial syndrome, and one eye with aphakia and glaucoma) were enucleated two to six years after implantation. Histopathologic examinations disclosed no evidence of erosion of sclera or conjunctiva of the eye by the glaucoma implant device. In the outer layers of the bleb wall, few and mostly degenerated inflammatory cells were present, which represented a minimal inflammatory reaction. Scanning electron microscopy of the tubes in these three patients showed that the tube was intact, patent, and without signs of degradation. The tube entering into the anterior chamber caused no appreciable inflammation and maintained its patency even when downgrowth epithelial cells lined the anterior chamber. The Molteno plate induced little or no inflammatory reaction. Therefore, the Molteno glaucoma implant is a useful device for patients with high risk for failure after surgery for glaucoma.