Physical activity and risk of multiple sclerosis: A Mendelian randomization study.
Physical activity and risk of multiple sclerosis: A Mendelian randomization study.
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体力活动和多发性硬化症的风险：孟德尔随机研究
DOI：
10.3389/fimmu.2022.872126
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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流行病学研究的多项证据表明体力活动与多发性硬化症 (MS) 风险之间存在关联。然而，研究之间的结论仍然存在争议，并且这种关联是因果关系还是混杂关系尚不清楚。为了评估不同强度的体力活动在多发性硬化症风险中的作用，我们首先估计了它们的遗传相关性，然后根据先前大型全基因组关联研究的汇总统计数据进行了双样本和多变量孟德尔随机化分析。中等体力活动与 MS 风险之间存在显着的遗传相关性（遗传相关性：-0.15，SE=0.05，P=2.9E-03）。同时，较高强度的体力活动与 MS 风险降低显着相关（OR：0.87，95％CI：0.80-0.96，P = 3.45E-03）。使用另一项关于整体身体活动的研究的汇总统计数据进一步验证了这种关联（OR：0.36，95％CI：0.17-0.76，P = 6.82E-03）。所有敏感性分析的结果都是稳健的。目前的结果表明，适度的体力活动可以降低患多发性硬化症的风险。这些发现有助于更好地了解体力活动在多发性硬化症中的作用，并为易患多发性硬化症的个体提供一些生活方式建议。
Multiple evidence from epidemiological studies has suggested association between physical activity and risk of multiple sclerosis (MS). However, the conclusion was still controversial between studies, and whether the association was causal or confounded is elusive. To evaluate the role of physical activity with different intensities in the risk of MS, we first estimated their genetic correlation, and then conducted two-sample and multivariable Mendelian randomization analyses based on summary statistics from previous large genome-wide association studies. A significant genetic correlation was identified between moderate physical activity and the risk of MS (genetic correlation: -0.15, SE=0.05, P=2.9E-03). Meanwhile, higher moderate physical activity was significantly associated with a reduced risk of MS (OR:0.87, 95% CI:0.80-0.96, P=3.45E-03). Such association was further verified using summary statistics from another study on overall physical activity (OR:0.36, 95% CI:0.17-0.76, P=6.82E-03). The results were robust under all sensitivity analyses. Current results suggested moderate physical activity could reduce the risk of MS. These findings help better understand the role of physical activity in MS, and provide some lifestyle recommendations for individuals susceptible to MS.