Calpain
Calpain
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DOI：
10.1016/s1357-2725(02)00009-2
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发表时间：
2002-07-01
影响因子：
4
通讯作者：
Huttenlocher, A
中科院分区：
文献类型：
--
作者：
Perrin, BJ;Huttenlocher, A
钙依赖的硫醇蛋白水解酶，钙蛋白水解酶，广泛表达的普遍存在和组织特异性的异构体。钙调蛋白参与了细胞的增殖、凋亡和分化等基本细胞过程。目前综述的重点是总结最近发现的与细胞骨架重排和细胞迁移有关的钙调蛋白。Calain可裂解许多胞浆蛋白，因此，要有效且受其作用范围的限制，其活性必须在时间和空间上受到严格的调控。一些调节机制包括钙、生长因子介导的磷酸化和膜靶向。抑制钙调蛋白可降低迁移速度并抑制细胞侵袭。钙蛋白酶在迁移过程中的两种可能作用机制包括：作为信号中间体的作用，作用于Rho的上游，以及对局部黏附结构和拆解的影响。因此，钙蛋白酶和下游信号分子可能是未来治疗癌症或慢性炎症的治疗干预的靶点。(C)2002爱思唯尔科学有限公司。保留所有权利。
The calcium-dependent thiol proteases, calpains, are widely expressed with ubiquitous and tissue specific isoforms. Calpains have been implicated in basic cellular processes including cell proliferation, apoptosis and differentiation. The focus of the current review is to summarize recent findings implicating calpains in cytoskeletal rearrangements and cell migration. Calpain cleaves many cytosolic proteins and therefore to be effective and limited in its scope, calpain activity has to be tightly regulated both temporally and spatially. Some mechanisms of regulation include calcium, growth factor-mediated phosphorylation and membrane targeting. Calpain inhibition reduces migration rates and inhibits cell invasiveness. Two putative mechanisms of calpain action during migration include its role as a signaling intermediate, acting upstream of Rho, and its effects on focal adhesion structure and disassembly. Therefore, calpains and downstream signaling molecules may be future targets for therapeutic interventions to treat cancer or chronic inflammation. (C) 2002 Elsevier Science Ltd. All rights reserved.