Phenotype of asthma related with high serum periostin levels
Phenotype of asthma related with high serum periostin levels
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DOI：
10.1016/j.alit.2014.07.003
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发表时间：
2015-04-01
影响因子：
6.8
通讯作者：
Betsuyaku, Tomoko
中科院分区：
文献类型：
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作者：
Matsusaka, Masako;Kabata, Hiroki;Betsuyaku, Tomoko
背景：哮喘是一种由多种表型组成的异质性疾病。骨膜蛋白是支气管上皮细胞中可被白细胞介素（IL）-4或IL-13诱导的分子，是“TH 2-高”哮喘的生物标志物。本研究的目的是探讨血清骨膜蛋白浓度是否与哮喘的严重程度，特异性表型（S），或合并症的asthma.Methods：血清骨膜蛋白浓度测定在190例日本哮喘患者和11名健康对照。该方案已在临床试验注册处注册为UMIN 000002980。血清骨膜蛋白浓度显着升高哮喘组[70.0（54.0-93.5）ng/ml]高于健康受试者[57.0（39.0-63.0）ng/ml]，但我们发现血清骨膜蛋白浓度与控制哮喘所需的治疗步骤之间没有相关性。为了表征“高骨膜蛋白”表型，基于骨膜蛋白的血清浓度将患有哮喘的患者分成三分之一。高骨膜蛋白组哮喘发作时年龄较大（P = 0.04），阿司匹林不耐受（P = 0.04）或伴随鼻部疾病（P = 0.03-0.001）的患病率较高，外周嗜酸性粒细胞计数较高（P < 0.001），肺功能较低（P = 0.02-0.07）。在伴有慢性鼻窦炎、鼻息肉和嗅觉障碍的哮喘患者中，血清骨膜蛋白浓度特别高。相比之下，无论是特应性状态，哮喘的控制状态，也没有生活质量与“高骨膜蛋白”phenotype.Conclusion：血清中骨膜蛋白浓度升高与嗜酸性粒细胞性哮喘，迟发性和经常并发阻塞性肺功能障碍和鼻腔疾病的特定表型相关。Copyright（C）2014，日本变态反应学会.制作和主办Elsevier B. V.保留所有权利。
Background: Asthma is a heterogeneous disease composed of various phenotypes. Periostin, a molecule inducible with interleukin (IL)-4 or IL-13 in bronchial epithelial cells, is a biomarker of "TH2-high" asthma. The objective of this study is to examine whether the serum periostin concentrations are correlated with the severity, specific phenotype(s), or comorbidity of asthma.Methods: Serum concentrations of periostin were measured in 190 Japanese asthmatic patients and 11 healthy controls. The protocol was registered under UMIN 000002980 in the clinical trial registry.Results: The serum concentrations of periostin were significantly higher (P = 0.014) in asthmatics [70.0 (54.0-93.5) ng/ml] than in healthy subjects [57.0 (39.0-63.0) ng/ml], though we found no correlation between serum periostin concentrations and treatment steps required to control asthma. To characterize "high-periostin" phenotype(s), the patients with asthma were divided among tertiles based on the serum concentrations of periostin. The high-periostin group was older at onset of asthma (P = 0.04), had a higher prevalence of aspirin intolerance (P = 0.04) or concomitant nasal disorders (P = 0.03-0.001), higher peripheral eosinophil counts (P < 0.001), and lower pulmonary function (P = 0.02-0.07). The serum concentrations of periostin were particularly high in asthmatic patients complicated by chronic rhinosinusitis with nasal polyps and olfactory dysfunction. In contrast, neither atopic status, control status of asthma, nor quality of life were related with the "high-periostin" phenotype.Conclusion: Elevated periostin concentrations in serum were correlated with a specific phenotype of eosinophilic asthma, late-onset and often complicated by obstructive pulmonary dysfunction and nasal disorders. Copyright (C) 2014, Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.