Effects of antiglucocorticoids on glucocorticoid hypertension in the rat.
Effects of antiglucocorticoids on glucocorticoid hypertension in the rat.
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抗糖皮质激素对大鼠糖皮质激素高血压的影响。
DOI：
10.1161/01.hyp.7.2.292
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发表时间：
1985
期刊：
影响因子：
8.3
通讯作者：
M. Worcel
中科院分区：
文献类型：
--
作者：
J. Grunfeld;L. Eloy;A. Moura;D. Ganeval;B. Ramos;M. Worcel
本文研究了糖皮质激素激动剂RU 26988诱发大鼠高血压的早期阶段。收缩压升高35 mm Hg。水和钠尿排泄一过性增加，血浆容量减少。总的和哇巴因敏感的钠流出，以及铷流出，增强了糖皮质激素的管理。低盐摄入并不能预防高血压。RU 38486（一种具有抗糖皮质激素特性的类固醇）预处理在很大程度上防止了血压升高（+10 mm Hg），并抑制了一过性尿钠排泄和血浆容量减少。总的和哇巴因敏感的钠外排的变化被完全阻止，而铷外排的变化仅部分逆转。同样，给予黄体酮（一种具有抗糖皮质激素作用的类固醇）可预防糖皮质激素性高血压（+11 mm Hg）和血管离子变化。相反，RU 28318（一种抗盐皮质激素药物）给药对糖皮质激素性高血压（+38 mm Hg）没有影响。在糖皮质激素后给予Progressive或RU 38486也可降低血压。目前的数据表明，糖皮质激素性高血压可以预防或逆转在其早期阶段的类固醇药物与抗糖皮质激素的性质。这些药物也似乎可以防止糖皮质激素诱导的钠和铷通量异常。我们认为血管糖皮质激素受体的激活可能参与了糖皮质激素性高血压的病理生理过程。
The early phase of hypertension induced in rats by a glucocorticoid agonist RU 26988 was studied. Systolic blood pressure increased by 35 mm Hg. Water and sodium urinary excretion increased transiently, and plasma volume decreased. Total and ouabain-sensitive sodium efflux, as well as rubidium efflux, were enhanced by glucocorticoid administration. Low salt intake did not prevent hypertension. Pretreatment with RU 38486, a steroid with antiglucocorticoid properties, largely prevented the rise in blood pressure (+10 mm Hg) and suppressed transient natriuresis and the decrease in plasma volume. Changes in total and ouabain-sensitive sodium efflux were completely prevented, whereas changes in rubidium efflux were only partly reversed. Similarly, administration of progesterone, a steroid with antiglucocorticoid effects, prevented glucocorticoid hypertension (+11 mm Hg) and vascular ionic changes. In contrast administration of RU 28318, an antimineralocorticoid agent, was without effect on glucocorticoid hypertension (+38 mm Hg). Progesterone or RU 38486 administered after glucocorticoid also decreased blood pressure. Present data indicate that glucocorticoid hypertension may be prevented or reversed in its early phase by steroid drugs with antiglucocorticoid properties. These drugs also appeared to prevent the sodium and rubidium flux abnormalities induced by glucocorticoid. We suggest that activation of the vascular glucocorticoid receptors may be involved in the pathophysiology of glucocorticoid hypertension.
血管收缩系统在大鼠实验性糖皮质激素高血压中的作用。
DOI：
10.1042/cs0650255
发表时间：
1983
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Waeber,B;Gavras,H;Bresnahan,MR;Gavras,I;Brunner,HR
通讯作者：
Brunner,HR
RU-26988——研究盐皮质激素受体的新工具。
影响因子：
4.8
作者：
Gomez-Sanchez,CE;Gomez-Sanchez,EP
通讯作者：
Gomez-Sanchez,EP