Somatosensory determinants of lordosis in female rats: behavioral definition of the estrogen effect.
Somatosensory determinants of lordosis in female rats: behavioral definition of the estrogen effect.
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雌性大鼠脊柱前凸的体感决定因素：雌激素效应的行为定义。
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
C. Lewis
中科院分区：
文献类型：
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作者：
D. Pfaff;M. Montgomery;C. Lewis
通过在雄性大鼠的腹部表面涂上一层染料，可以在雌性大鼠的毛发和皮肤上精确地记录雄性大鼠和雌性大鼠在交配过程中接触的区域。在雌性前凸开始和维持期间，雄性大鼠触摸雌性的侧腹、臀部、尾基、会阴和阴道周围表面。电影分析显示，雄性的爪子和骨盆的推力以每秒10到20次的频率刺激雌性的皮肤。实验者对男性接触的女性皮肤部位施加体感刺激。侧翼或会阴的头发偏转不会引起前凸。仅在给予高剂量雌激素和孕酮的雌性小鼠中，光同时刺激腹部和会阴引起前凸。当侧腹刺激后再对臀部、尾基和会阴施加压力时，激素治疗的雌性会诱发前凸。这里显示了反射的雌激素依赖性，黄体酮与雌激素效应协同作用。在前凸的组成部分中，臀部和头部的升高对臀部、尾基和会阴的压力刺激的反应似乎是激素敏感的。这些结果有助于确定前凸的最小皮肤感觉要求。反过来，雌激素对前凸的影响可以被定义为在侧腹刺激后对臀部、尾基和会阴皮肤压力的反应性增加。这些结果说明了雌激素、黄体酮和躯体感觉刺激是如何相互作用导致前凸的，一种因素强度的增加弥补了另一种因素强度的减少。
By coating the ventral surface of male rats with a dye, regions of contact between male and female during male mounting were recorded precisely on the female's hair and skin. The male rat touches the female's flanks, rump, tailbase, perineum, and perivaginal surfaces during the female's initiation and maintenance of lordosis. Film analyses showed that the male's paws and pelvic thrusting stimulate the female's skin with dominant frequencies between 10 and 20 per second. Somatosensory stimuli were applied by the experimenter to the female skin locations contacted by the male. Deflection of hair on the flanks or perineum alone did not cause lordosis. Light stimulation simultaneously on flanks and perineum caused lordosis only in some females given high estrogen dosages supplemented by progesterone. When flank stimuli were followed by pressure on the rump, tailbase, and perineum, lordosis was triggered reliably in hormone-treated females. Here the estrogen-dependence of the reflex was shown, and progesterone synergized with the estrogen effect. Among lordosis components, rump and head elevations in response to pressure stimuli on the rump, tailbase, and perineum appear to be hormone-sensitive. These results help to define the minimal cutaneous sensory requirement for lordosis. In turn, the estrogen effect on lordosis may be defined behaviorally as increased responsiveness to pressure on rump, tailbase, and perineal skin, after flank stimulation. These results illustrate how estrogen, progesterone, and somatosensory stimuli interact in causing lordosis, increases in the strength of one factor compensating for decreases in another.