RBP-J promotes the maturation of neuronal progenitors
RBP-J promotes the maturation of neuronal progenitors
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DOI：
10.1016/j.ydbio.2011.03.020
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发表时间：
2011-06-01
影响因子：
2.7
通讯作者：
Tanaka, Kohichi
中科院分区：
文献类型：
--
作者：
Komine, Okiru;Nagaoka, Mai;Tanaka, Kohichi
在大脑发育过程中，神经元和胶质细胞由神经干细胞和更有限的中间神经祖细胞（INPs）产生。大量研究揭示了神经干细胞的发育机制。然而，控制INPs发展的信号通路在很大程度上是未知的。小脑适合于研究这个问题，因为小脑皮层抑制性神经元，如篮状细胞和星状细胞，来自小的Pax 2（+）神经元间祖细胞。本研究表明，Sox 2（-）/Pax 2（+）和Sox 2（+）/Pax 2（-）祖细胞，即篮状细胞和星状细胞的两种类型的神经元间祖细胞，存在于小脑白色物质（WM）中，并且前者在出生后第一周内由后者产生。此外，RBP-J通过将Sox 2（+）/Pax 2（-）神经元间祖细胞转化为更成熟的Sox 2（-）/Pax 2（+）神经元间祖细胞来促进星状细胞和篮状细胞的神经发生。这项研究显示了一种新的RBP-J功能，可促进INP分化。(c)2011 Elsevier Inc. All rights reserved.
During brain development, neurons and glias are generated from neural stem cells and more limited intermediate neural progenitors (INPs). Numerous studies have revealed the mechanisms of development of neural stem cells. However, the signaling pathways that govern the development of INPs are largely unknown. The cerebellum is suitable for examining this issue because cerebellar cortical inhibitory neurons such as basket and stellate cells are derived from small Pax2(+) interneuronal progenitors. Here, we show that Sox2(-)/Pax2(+) and Sox2(+)/Pax2(-) progenitors, 2 types of interneuronal progenitors of basket and stellate cells, exist in the cerebellar white matter (WM) and that the former arise from the latter during the first postnatal week. Moreover, RBP-J promotes the neurogenesis of stellate and basket cells by converting Sox2(+)/Pax2(-) interneuronal progenitors to more mature Sox2(-)/Pax2(+) interneuronal progenitors. This study shows a novel RBP-J function that promotes INP differentiation. (c) 2011 Elsevier Inc. All rights reserved.