Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats.
Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats.
复制标题
慢性反复爆炸性脑损伤与大鼠寻求羟考酮的增加有关。
DOI：
10.1016/j.bbr.2022.114181
复制
发表时间：
2023
影响因子：
2.7
通讯作者：
Olsen,ChristopherM
中科院分区：
文献类型：
--
作者：
Chiariello,Rachel;McCarthy,Cassandra;Glaeser,BreannaL;Shah,AlokS;Budde,MatthewD;Stemper,BrianD;Olsen,ChristopherM
许多流行病学研究发现，非严重创伤性脑损伤（TBI）和药物滥用在平民和军人人群中存在共病现象。临床前研究也确定了一些滥用物质的这种关系。我们之前已经证明，反复冲击创伤性脑损伤（rbTBI）增加了羟考酮的寻求，而没有增加羟考酮的自我管理，这表明创伤性脑损伤的神经系统后遗症可以提高阿片类药物滥用的可能性。在这里，我们通过测试损伤和羟考酮自我给药之间的不同持续时间和禁欲持续时间来确定这种影响的长期性。我们发现，损伤和羟考酮自我给药之间的亚慢性（4周），而不是急性（3天）或慢性（4个月）持续时间与10天禁欲后寻求药物和重新获得自我给药的增加相关。其他禁欲持续时间（两天，四周或四个月）的检查显示，在任何测试的禁欲持续时间的rbTBI对药物寻求没有影响。总之，这些数据表明，当羟考酮自我给药与药物寻求和复发相关行为增加相关时，TBI后存在脆弱性窗口。
Numerous epidemiological studies have found co-morbidity between non-severe traumatic brain injury (TBI) and substance misuse in both civilian and military populations. Preclinical studies have also identified this relationship for some misused substances. We have previously demonstrated that repeated blast traumatic brain injury (rbTBI) increased oxycodone seeking without increasing oxycodone self-administration, suggesting that the neurological sequelae of traumatic brain injury can elevate opioid misuse liability. Here, we determined the chronicity of this effect by testing different durations of time between injury and oxycodone self-administration and durations of abstinence. We found that the subchronic (four weeks), but not the acute (three days) or chronic (four months) duration between injury and oxycodone self-administration was associated with increased drug seeking and re-acquisition of self-administration following a 10-day abstinence. Examination of other abstinence durations (two days, four weeks, or four months) revealed no effect of rbTBI on drug seeking at any of the abstinence durations tested. Together, these data indicate that there is a window of vulnerability after TBI when oxycodone self-administration is associated with elevated drug seeking and relapse-related behaviors.