BDNF is Required for the Induction of a Presynaptic Component of the Functional Conversion of Silent Synapses
BDNF is Required for the Induction of a Presynaptic Component of the Functional Conversion of Silent Synapses
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DOI：
10.1002/hipo.20754
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发表时间：
2011-04-01
期刊：
影响因子：
3.5
通讯作者：
Buno, Washington
中科院分区：
文献类型：
--
作者：
Cabezas, Carolina;Buno, Washington
长时程增强（LTP）由于其在学习和记忆中的作用而受到关注。尽管大量的努力，前或突触后的LTP表达网站仍然不稳定。已经提出LTP通过“沉默突触”的功能转换在突触后表达。我们已经证明，谢弗侧支（SC）沉默和“功能性突触”，缺乏和表达AMPA受体，分别表现出不同的递质释放特性。因此，沉默突触的功能转换与LTP应该与突触前修饰。我们现在表明，配对诱导的LTP在SC突触介导的突触前和突触后的修改，涉及突触后出现的AMPA反应加上增强的谷氨酸释放相结合。BDNF通过激活TrkBR复制与这种LTP相关的变化，这表明神经营养因子是突触间隙两侧协调变化所必需的。(C)2010 Wiley-Liss，Inc.
Long-term potentiation (LTP) has received attention because of its proposed role in learning and memory. Despite substantial effort the pre- or postsynaptic expression site of LTP remains unsettled. It has been proposed that LTP is expressed postsynaptically through the functional conversion of "silent synapses." We had shown that Schaffer collateral (SC) silent and "functional synapses," which lack and express AMPA receptors, respectively exhibit distinct transmitter release properties. Therefore the functional conversion of silent synapses with LTP should be associated with presynaptic modifications. We now show that the pairing-induced LTP at SC synapses is mediated by combined pre- and postsynaptic modifications involving the postsynaptic emergence of an AMPA response coupled with an enhanced glutamate release. BDNF replicates the changes associated with this LTP by activating TrkBRs, suggesting that the neurotrophin is required for the coordinated changes on both sides of the synaptic cleft. (C) 2010 Wiley-Liss, Inc.