Serum extracellular vesicles profiling is associated with COVID-19 progression and immune responses.
Serum extracellular vesicles profiling is associated with COVID-19 progression and immune responses.
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DOI：
10.1002/jex2.37
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发表时间：
2022-04
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冠状病毒病2019年(新冠肺炎)很快转变为一场世界大流行，对人类健康造成严重和意想不到的后果。一直在共同努力，以产生更好的诊断和预测工具。到目前为止，研究主要集中在病毒本身或对它的直接免疫反应上。在这里，我们建议从血清液活检中提取细胞外小泡(EVS)作为一种新的、独特的方式来统一新冠肺炎分析的诊断和预后工具。EV在细胞间信号传递方面是一个新的参与者，特别是影响免疫反应。我们在此展示了先天和获得性免疫EVS特征，以及SARS-CoV-2尖峰S1+EVS为SARS-CoV-2感染提供了一个新的标志。它还提供了一种独特的能力，将病毒和宿主细胞特征的共存联系起来，以监测受影响的组织和疾病进展的严重程度。并提供了与COVID相关的电动汽车的表型洞察力。
Coronavirus disease 2019 (COVID‐19) has transformed very quickly into a world pandemic with severe and unexpected consequences on human health. Concerted efforts to generate better diagnostic and prognostic tools have been ongoing. Research, thus far, has primarily focused on the virus itself or the direct immune response to it. Here, we propose extracellular vesicles (EVs) from serum liquid biopsies as a new and unique modality to unify diagnostic and prognostic tools for COVID‐19 analyses. EVs are a novel player in intercellular signalling particularly influencing immune responses. We herein show that innate and adaptive immune EVs profiling, together with SARS‐CoV‐2 Spike S1+ EVs provide a novel signature for SARS‐CoV‐2 infection. It also provides a unique ability to associate the co‐existence of viral and host cell signatures to monitor affected tissues and severity of the disease progression. And provide a phenotypic insight into COVID‐associated EVs.