Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism.
Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism.
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造血干细胞代谢中的线粒体更新和溶酶体功能。
DOI：
10.3390/ijms22094627
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发表时间：
2021-04-28
影响因子：
5.6
通讯作者：
Nakamura-Ishizu A
中科院分区：
文献类型：
--
作者：
Mochizuki-Kashio M;Shiozaki H;Suda T;Nakamura-Ishizu A
造血干细胞(HSCs)存在于低氧微环境中，可促进糖酵解代谢，减少氧化应激。然而，线粒体和溶酶体等细胞器中的代谢调节以及自噬过程被认为是决定HSC细胞命运的关键。该综述包括目前对HSCs无氧代谢的了解，以及线粒体代谢和溶酶体调节对造血稳态的新作用。
Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic regulation in organelles such as the mitochondria and lysosomes as well as autophagic processes have been implicated as essential for the determination of HSC cell fate. This review encompasses the current understanding of anaerobic metabolism in HSCs as well as the emerging roles of mitochondrial metabolism and lysosomal regulation for hematopoietic homeostasis.