Environmentally sustainable production and application of acyl phosphates
Environmentally sustainable production and application of acyl phosphates
复制标题
酰基磷酸盐的环境可持续生产和应用
DOI：
10.1039/d0gc02370a
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发表时间：
2020-11-07
期刊：
影响因子：
9.8
通讯作者：
Cai, Hu
中科院分区：
文献类型：
--
作者：
Guo, Shengmei;Li, Sen;Cai, Hu
报道了一种多用途、环境友好的酰基磷酸酯合成方法。通过采用电化学氧化还原偶联，这种转化具有广泛的底物，以及无金属，无氧化剂和温和的条件。在不使用任何催化剂和添加剂的情况下，以酰基磷酸酯和胺为原料，在室温下2h内高效、区域选择性地合成了酰胺。根据控制实验提出了该机理。
A versatile and environmentally friendly synthetic method for the formation of acyl phosphates is reported. By employing electrochemical oxidative dehydrogenative coupling, this transformation features a broad range of substrates, as well as metal-free, oxidant-free and mild conditions. One-pot synthesis of amides from acyl phosphates with amines was accomplished with high efficiency and regioselectivity, without using any additional catalysts and additives, within 2 hours under room temperature. The mechanism is proposed according to the control experiments.