Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs
Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs
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DOI：
10.1007/s10620-005-2770-y
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发表时间：
2005-07-01
影响因子：
3.1
通讯作者：
Takahashi, T
中科院分区：
文献类型：
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作者：
Iwa, M;Strickland, C;Takahashi, T
研究表明，针灸可以缓解肠易激综合征（IBS）患者的腹痛和腹胀症状。然而，针灸的有益作用机制仍未得到证实。本研究的目的是探讨针灸对清醒狗的镇痛作用机制。我们将直肠扩张引起的平均动脉血压（MAP）升高作为内脏疼痛的指标进行评估。 ST 36（小腿）处的电针（EA；10 Hz）显着降低了直肠扩张（30 和 40 cm(3)）引起的 MAP 增加，但 BL-21（背部）则不然。 EA 在 ST-36 的镇痛作用可通过纳洛酮（一种中枢和外周阿片受体拮抗剂）预处理而消除，但不会被纳洛酮甲硫氨酸（一种外周阿片受体拮抗剂）消除。这些结果表明 ST-36 处的 EA 可能通过中枢阿片类途径减轻内脏疼痛。针灸可能有助于治疗 IBS 患者的内脏过敏症。
It has been shown that acupuncture relieves symptoms of abdominal pain and bloating in patients with irritable bowel syndrome (IBS). However, the mechanism of beneficial effects of acupuncture still remains unproven. The aim of the present study was to investigate the mechanisms of the antinociceptive effects of acupuncture in conscious dogs. We evaluated the increase in mean arterial blood pressure (MAP) caused by rectal distension as an index of visceral pain. Electroacupuncture (EA; 10 Hz) at ST 36 (lower leg), but not at BL-21 (back), significantly reduced the increase in MAP in response to rectal distension (30 and 40 cm(3)). The antinociceptive effect of EA at ST-36 was abolished by pretreatment with naloxone (a central and peripheral opioid receptor antagonist) but not by naloxone methiodide (a peripheral opioid receptor antagonist). These results suggest that EA at ST-36 may reduce visceral pain via central opioid pathway. Acupuncture may be useful to treat visceral hypersensitivity in IBS patients.