Solid cancers after allogeneic hematopoietic cell transplantation
Solid cancers after allogeneic hematopoietic cell transplantation
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DOI：
10.1182/blood-2008-05-158782
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发表时间：
2009-01-29
期刊：
影响因子：
20.3
通讯作者：
Deeg, H. Joachim
中科院分区：
文献类型：
--
作者：
Rizzo, J. Douglas;Curtis, Rochelle E.;Deeg, H. Joachim
据报道，移植受者患实体癌的风险增加，但大多数研究规模小，评估宿主、疾病和治疗相关因素相互作用的能力有限。在迄今为止规模最大的评估实体癌危险因素的研究中，我们研究了28874名患有189种实体恶性肿瘤的同种异体移植受者的多机构队列。总体而言，患者发生新的实体癌的比率是基于一般人群比率的预期比率的两倍（观察到的预期比为2.1；95%置信区间为1.8-2.5），并且随着时间的推移风险增加（P趋势）
Transplant recipients have been reported to have an increased risk of solid cancers but most studies are small and have limited ability to evaluate the interaction of host, disease, and treatment-related factors. In the largest study to date to evaluate risk factors for solid cancers, we studied a multi-institutional cohort of 28 874 allogeneic transplant recipients with 189 solid malignancies. Overall, patients developed new solid cancers at twice the rate expected based on general population rates (observed-to-expected ratio 2.1; 95% confidence interval 1.8-2.5), with the risk increasing over time (P trend