Evaluation of Myanmar Medicinal Plant Extracts for Antitrypanosomal and Cytotoxic Activities
Evaluation of Myanmar Medicinal Plant Extracts for Antitrypanosomal and Cytotoxic Activities
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DOI：
10.1292/jvms.09-0508
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发表时间：
2010-04-01
影响因子：
1.2
通讯作者：
Katakura, Ken
中科院分区：
文献类型：
--
作者：
Bawm, Saw;Tiwananthagorn, Saruda;Katakura, Ken
目前人类和牲畜中非洲锥虫病的化疗选择非常有限。在本研究中。从缅甸采集的60种植物中共筛选了71种药用植物标本，用于体外抗伊氏锥虫的抗锥虫活性和对MRC-5细胞的细胞毒性。葡萄属匍匐茎干根皮的甲醇提取物显示出最高的抗锥虫活性，IC 50值为8.6 +/- 1.5 μ g/ml，最高选择性指数为24.4。鸦胆子、蔓荆子、蓝桉和毛果麻风树的提取物也有明显的活性，IC_（50）值和选择性指数分别在27.2-52.6 μ g/ml和11.4-15.1之间。
Current chemotherapeutic options for African trypanosomiasis in humans and livestock are very limited. In the present study. a total of 71 medicinal plant specimens from 60 plant species collected M Myanmar were screened for antitrypanosomal activity against trypomastigotes of Trypanosoma evansi and cytotoxicity against MRC-5 cells in vitro. The methanol extract of dried rootbark of Vitis repens showed the highest antitrypanosomal activity with IC50 value of 8.6 +/- 1.5 mu g/ml and the highest selectivity index of 24.4. The extracts of Brucea javanica, Vitex arborea, Eucalyptus globulus and Jatropho podagrica bad also remarkable activity with IC50 values and selectivity indices in the range of 27.2-52.6 mu g/ml and 11.4-15.1 respectively.