Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection
Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection
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DOI：
10.1111/j.1574-6968.2002.tb11145.x
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发表时间：
2002-04-09
影响因子：
2.1
通讯作者：
Gerlach, GF
中科院分区：
文献类型：
--
作者：
Baltes, N;Hennig-Pauka, I;Gerlach, GF
构建了三种遗传学定义的胸膜肺炎放线杆菌血清型7突变体，其小突变体（tbpB）、大突变体（tbpA）和两种转铁蛋白结合蛋白基因缺失，并在气溶胶感染模型中进行了研究。这两种突变体均未引起临床疾病，也未被重新分离，感染后21天未检测到免疫应答。这一结果清楚地表明，每个转铁蛋白结合蛋白本身就是A.胸膜肺炎血清型7。(C)2002年，欧洲微生物学会联合会。由Elsevier Science B.V.出版，版权所有。
Three genetically defined Actinobacillus pleuropneumoniae serotype 7 mutants with deletions in the small (tbpB), the large (tbpA), and both transferrin binding protein genes were constructed and examined in an aerosol infection model. Neither mutant caused clinical disease or could be reisolated, and no immune response could be detected 21 days after infection. This result clearly implies that each transferrin binding protein on its own is a virulence factor of A. pleuropneumoniae serotype 7. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.