Degradable thiol-acrylate photopolymers: polymerization and degradation behavior of an in situ forming biomaterial
Degradable thiol-acrylate photopolymers: polymerization and degradation behavior of an in situ forming biomaterial
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DOI：
10.1016/j.biomaterials.2004.11.046
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发表时间：
2005-08-01
期刊：
影响因子：
14
通讯作者：
Anseth, KS
中科院分区：
文献类型：
--
作者：
Rydholm, AE;Bowman, CN;Anseth, KS
可降解的硫醇-丙烯酸酯光聚合物是一类新型生物材料，其在生理条件下暴露于UV光时能够快速聚合，添加或不添加光引发剂，并且深度超过10 cm。这些材料是原位形成的，其化学性质的多功能性提供了对最终材料性能的高度控制。例如，单体摩尔分数的变化直接影响最终的网络分子结构，使实现完全质量损失所需的时间从25天变化到100天，降解产物的分子量分布以及整个降解过程中的溶胀比和压缩模量。另外，改变初始反应混合物中多官能硫醇单体的摩尔分数控制可用于聚合物的聚合后改性的网络中的反应性位点的浓度。(c)2004爱思唯尔有限公司保留所有权利。
Degradable thiol-acrylate photopolymers are a new class of biomaterials capable of rapidly polymerizing under physiological conditions upon exposure to UV light, with or without added photoinitiators, and to depths exceeding 10 cm. These materials are formed in situ, and the versatility of their chemistry affords a high degree of control over the final material properties. For example, variations in monomer mole fractions directly affect the final network molecular structure, varying the time required to achieve complete mass loss from 25 to 100 days, the molecular weight distributions of the degradation products, and the swelling ratios and compressive moduli throughout degradation. Additionally, varying the mole fraction of multifunctional thiol monomer in the initial reaction mixture controls the concentration of reactive sites in the network available for post-polymerization modification of the polymer. (c) 2004 Elsevier Ltd. All rights reserved.