Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance
Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance
复制标题
四溴双酚 A (TBBPA) 对革兰氏阳性菌具有特定的抗菌活性，且未检测到耐药性。
DOI：
10.1039/c7cc00613f
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发表时间：
2017
影响因子：
4.9
通讯作者：
Liang Yong
中科院分区：
文献类型：
--
作者：
Ji Fang;Wang Chang;Wang Huimin;Liu Guangliang;Chen Bolei;Hu Ligang;Jiang Guibin;Song Maoyong;Liang Yong
我们在这里报告了四溴双酚A （TBBPA）对革兰氏阳性细菌的抗菌能力，而没有检测到耐药性。显微镜成像和基因分析表明，细菌细胞壁是TBBPA的靶点。TBBPA及其类似物的结构-活性研究将抗菌活性与邻酚羟基的卤素取代联系起来。
We report here the antimicrobial ability of tetrabromobisphenol A (TBBPA) against Gram-positive bacteria without detectable resistance. Microscopy imaging and gene analysis reveal that the bacterial cell wall is the target of TBBPA. Structure–activity studies of TBBPA and its analogues relate the observed antimicrobial activity to the halogen substitution neighboring the phenolic hydroxyl group.