In vitro effect of phagocyte cationic peptides on Coccidioides immitis.
In vitro effect of phagocyte cationic peptides on Coccidioides immitis.
复制标题
吞噬细胞阳离子肽对粗球孢子菌的体外作用。
DOI：
10.1093/infdis/151.5.890
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Selsted,ME
中科院分区：
文献类型：
--
作者：
Segal,GP;Lehrer,RI;Selsted,ME
Several cationic peptides that were isolated from rabbit granulocytes exerted fungicidal activity against arthroconidia ofCoccidioides immitisin vitro. The fungicidal effect of the cationic peptides required at least 4–8 hr of contact between peptide and fungal cells and appeared to be dependent upon active fungal metabolism. The fungicidal activity was inhibited by increases in the tonicity of the growth medium but was not inhibited by changes in pH. These findings provide a potential mechanism whereby phagocytic cells may limit the spread of infection due toC. immitis.
