INDUCTION OF RESISTANCE TO SCHISTOSOMA-MANSONI BY NATURAL CORD FACTOR AND SYNTHETIC LOWER HOMOLOGS
INDUCTION OF RESISTANCE TO SCHISTOSOMA-MANSONI BY NATURAL CORD FACTOR AND SYNTHETIC LOWER HOMOLOGS
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DOI：
10.1093/infdis/141.4.473
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发表时间：
1980-01-01
影响因子：
6.4
通讯作者：
MAHMOUD, AAF
中科院分区：
文献类型：
--
作者：
OLDS, GR;CHEDID, L;MAHMOUD, AAF
小鼠对血吸虫病的抵抗力可通过S. mansoni或非特异性地通过用各种不相关的试剂如BCG治疗。检测了几种与分枝杆菌相关的免疫佐剂诱导血吸虫病抗性的能力。天然脐带因子（6，6“-海藻糖二霉菌酸酯），一种100碳合成脐带因子类似物和二棕榈酸海藻糖诱导显著保护。海藻糖二山嵛酸酯和胞壁酰二肽没有诱导一致的保护作用。由于通过原发性染色体感染或任何这些增效剂获得的保护是部分的，因此评价了它们可能的累加效应。注射海藻糖二棕榈酸酯和攻击的日本血吸虫病小鼠的抵抗力增加，作为测定从肺中回收的童虫和从门静脉系统中回收的成虫。这些合成佐剂诱导部分保护，对血吸虫病，并显着提高获得性免疫小鼠与原发感染。
Resistance to schistosomiasis in mice can be acquired specifically by primary infection with S. mansoni or non-specifically by treatment with a variety of unrelated agents such as BCG. Several immunoadjuvants related to mycobacteria were examined for their ability to induce resistance to schistosomiasis. Natural cord factor (6,6''-trehalose dimycolate), a 100-carbon synthetic cord factor analog and dipalmitate trehalose induced significant protection. Trehalose dibehenate and muramyl dipeptide did not induce consistent protection. Since protection acquired by primary schistosomal infection or by any of these potentiating agents is partial, their possible additive effect was evaluated. The resistance of mice with schistosomiasis that were injected with trehalose dipalmitate and challenged with schistosomal cercariae was increased, as assayed by recovery of schistosomula from the lungs and of adult worms from the portal system. These synthetic adjuvants induce partial protection against schistosomiasis and significantly enhance acquired immunity in mice with primary infections.