Effects of sexual experience on conspecific odor preference and male odor-induced activation of the vomeronasal projection pathway and the nucleus accumbens in female rats
Effects of sexual experience on conspecific odor preference and male odor-induced activation of the vomeronasal projection pathway and the nucleus accumbens in female rats
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DOI：
10.1016/j.brainres.2007.07.071
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发表时间：
2007-10-17
期刊：
影响因子：
2.9
通讯作者：
Chiba, Atsuhiko
中科院分区：
文献类型：
--
作者：
Hosokawa, Nami;Chiba, Atsuhiko
在本研究中，雌激素-孕酮引发卵巢切除的雌性大鼠，我们研究了表达的偏好，男性气味和男性气味诱导的Fos免疫反应性整个犁鼻投射通路和神经核（NAcc），使用性经验和性幼稚的科目。雌性大鼠显着的首选空气中的气味和肮脏的床上用品从性活跃的男性在那些发情期的女性，无论是否存在先前的性经验。另一方面，暴露于男性弄脏的床上用品显着增加Fos表达的大脑区域是不同的性经验和性幼稚的科目。Fos在两组受试者的前脑背内侧杏仁核（MePD）和终纹床核（BNST）以及副嗅球中的表达均显著增加。然而，Fos在前背内侧杏仁核（MeAD），内侧视前区（mPOA）和NAcc核心的表达显着增加，只有在性经验的科目。这些结果表明，男性气味诱导的激活的MePD和/或BNST，但不是MeAD，mPOA和NAcc的核心，需要表达的男性定向气味偏好在雌性大鼠。(C)2007 Elsevier B. V.保留所有权利。
In the present study in estrogen-progesterone primed ovariectomized female rats, we examined the expression of a preference for male odors and male odor-induced Fos immunoreactivity throughout the vomeronasal projection pathway and the nucleus accumbens (NAcc), using both sexually experienced and sexually naive subjects. Female rats significantly preferred airborne odors and soiled bedding from sexually active males over those from estrous females, irrespective of the presence or absence of prior sexual experience. On the other hand, the brain regions in which exposure to male-soiled bedding significantly increased Fos expression were different between sexually experienced and sexually naive subjects. Significant increment of Fos expression in the posterior-dorsal medial amygdala (MePD) and the bed nucleus of stria terminalis (BNST) in forebrain, as well as the accessory olfactory bulb, was observed in both groups of subjects. Fos expression in the anterior-dorsal medial amygdala (MeAD), the medial preoptic area (mPOA) and the NAcc core, however, was significantly increased only in the sexually experienced subjects. These results suggested that male odor-induced activations of the MePD and/or the BNST, but not of the MeAD, the mPOA and the NAcc core, are required for the expression of a male-directed odor preference in female rats. (C) 2007 Elsevier B.V. All rights reserved.