Cytodiagnostic urinalysis is very useful in the differential diagnosis of acute renal failure and can predict the severity
Cytodiagnostic urinalysis is very useful in the differential diagnosis of acute renal failure and can predict the severity
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DOI：
10.3109/08860229509037640
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发表时间：
1995-01-01
期刊：
影响因子：
3
通讯作者：
Kjellstrand, C
中科院分区：
文献类型：
--
作者：
Marcussen, N;Schumann, J;Kjellstrand, C
测试了细胞诊断尿液分析以确定其在急性肾衰竭（ARF）鉴别诊断中的效用。纳入了 51 名急性肾衰竭患者，并对肾衰竭的病因、是否存在潜在的慢性肾衰竭以及是否需要透析进行了临床评估。对尿液样本进行宏观检查并进行多参数试剂条分析。对细胞离心制剂进行巴氏染色，并以标准化方式检查血细胞、肾细胞和管型的数量。结果显示，与 17 名非 ATN 患者相比，34 名缺血性或中毒性急性肾小管坏死 (ATN) 患者的集合管细胞数量较多，管型总数也较多。与 39 名不需要透析的患者相比，12 名需要透析的患者有更多不同类型的管型（颗粒状、蜡状、白细胞、广泛管型）以及更多的肾细胞（主要是坏死）。血清肌酐升高幅度与许多细胞诊断参数之间存在显着的正相关性。我们的结论是，除了其他测试之外，细胞诊断尿液分析对于评估急性肾衰竭患者可能也很有价值。
Cytodiagnostic urinalysis was tested to determine its utility in the differential diagnosis of acute renal failure (ARF). Fifty-one patients with acute renal failure were included and evaluated clinically with regard to the etiology of the renal failure, whether underlying chronic renal failure was present, and if dialysis was required. Urine specimens were macroscopically examined and subjected to a multiparameter reagent-strip analysis. Papanicolaou stain was done on cytocentrifuge preparations and the number of blood cells, renal cells, and casts examined in a standardized fashion. The results showed that the 34 patients with acute tubular necrosis (ATN) of either ischemic or toxic origin had a higher number of collecting duct cells, and a higher total number of casts than the 17 non-ATN patients. Twelve patients requiring dialysis had a higher number of different types of casts (granular, waxy, leukocytic, broad casts) as well as more renal cells (mainly necrotic) than the 39 patients who did not require dialysis. A significant positive correlation was found between the magnitude of rise of serum creatinine and a number of cytodiagnostic parameters. We conclude that cytodiagnostic urinalysis may be valuable in addition to other tests in the evaluation of patients with acute renal failure.