Chlorogenic Acid Ameliorates High-Fat and High-Fructose Diet-Induced Cognitive Impairment via Mediating the Microbiota-Gut-Brain Axis.
Chlorogenic Acid Ameliorates High-Fat and High-Fructose Diet-Induced Cognitive Impairment via Mediating the Microbiota-Gut-Brain Axis.
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DOI：
10.1021/acs.jafc.1c07479
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发表时间：
2022-02
影响因子：
6.1
通讯作者：
Shu Qing Zhang;D. Tian;C. Hu;Y. Meng
中科院分区：
文献类型：
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作者：
Shu Qing Zhang;D. Tian;C. Hu;Y. Meng
绿原酸（CGA）具有改善认知的特性，但其潜在机制仍不清楚。在此，补充 CGA（150 毫克/公斤体重）14 周可显着预防由高脂肪和高果糖饮食 (HFFD) 引起的肥胖和胰岛素抵抗、认知行为障碍和突触功能障碍。此外，补充 CGA 增强了富含神经活性配体-受体相互作用途径的基因的表达，并减少了炎症因子的表达。此外，CGA 治疗增加了肠道微生物群的多样性和产生 SCFA 的细菌属的水平。 CGA 还降低了能量代谢底物的浓度，同时增加了磷酸胆碱。最后，我们通过靶向多组学分析观察到 CGA 补充剂组中突触传递基因、肠道微生物群和神经传递之间存在显着相关性。总之，我们的结果支持肠道微生物群和代谢物组成的改变是 CGA 改善认知功能的潜在机制。 CGA 也是一种有前景的干预策略，可预防 HFFD 引起的认知障碍。
Chlorogenic acid (CGA) displays cognition-improving properties, but the underlying mechanisms remain unclear. Herein, CGA supplementation (150 mg/kg body weight) for 14 weeks significantly prevented obesity and insulin resistance, cognitive-behavioral disturbances, and synaptic dysfunction induced by a high-fat and high-fructose diet (HFFD). Moreover, CGA supplementation enhanced the expression of genes enriched in the neuroactive ligand-receptor interaction pathway and reduced inflammatory factor expressions. Furthermore, CGA treatment increased gut microbiota diversity and the level of bacterial genera producing SCFAs. CGA also decreased the concentration of energy metabolism substrates, while it increased phosphorylcholine. Finally, we observed a significant correlation among synaptic transmission genes, gut microbiota, and neurotransmission in the CGA supplementation group by targeted multiomics analysis. Together, our results supported that the alteration of gut microbiota and metabolite composition is the underlying mechanism of CGA improving cognitive function. CGA is also a promising intervention strategy to prevent HFFD-induced cognitive impairment.