Tumor necrosis factor is not involved in exercise-induced elevation in core temperature.
Tumor necrosis factor is not involved in exercise-induced elevation in core temperature.
复制标题
肿瘤坏死因子不参与运动引起的核心温度升高。
DOI：
10.1152/ajpregu.1993.265.6.r1351
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Kluger,MJ
中科院分区：
文献类型：
--
作者：
Rowsey,PJ;Borer,KT;Kluger,MJ
雌性Sprague-Dawley大鼠（12：12-h光-暗光周期），在运动期间（夜间）和非运动期间（白天）都有一个升高的体温（BT）。我们研究了运动诱导的BT增加是否受细胞因子肿瘤坏死因子-α（TNF）释放的调节。运动开始两周后，运动大鼠的夜间温度比运动前升高约0.5摄氏度（P = 0.006）。运动开始后3周，白天的温度比对照水平高出0.3摄氏度（P = 0.03）。为了证实内源性产生的TNF可以调节雌性大鼠的发热，我们在腹腔内注射脂多糖（50微克/千克）前24小时给6只大鼠注射TNF抗血清（300微升/只）和6只大鼠注射对照血清。与早期对雄性大鼠的研究一样，抗血清处理的雌性大鼠发热显著增强（P = 0.017）。为了确定内源性产生的TNF是否参与调节白天和夜间BT的增加，在运动大鼠中腹膜内注射TNF抗血清（300微升/大鼠，n = 7）或对照血清（300微升/大鼠，n = 5）。无论是注射抗血清或对照血清对白天或夜间的BT有任何影响。由于BT运动雌性大鼠注射抗TNF的抗血清没有受到影响，我们得出结论，TNF是不负责调制他们的运动引起的BT上升。
Female Sprague-Dawley rats (12:12-h light-dark photoperiod) with access to running wheels have an elevated body temperature (BT) both during exercise (nighttime) and nonexercise periods (daytime). We studied whether the exercise-induced increase in BT is modulated by the release of the cytokine, tumor necrosis factor-alpha (TNF). Two weeks after the onset of exercise, nighttime temperatures of exercising rats were elevated approximately 0.5 degree C compared with preexercise values (P = 0.006). By 3 wk after the onset of exercise, daytime temperatures had increased 0.3 degree C (P = 0.03) above control levels. To confirm that endogenously produced TNF can modulate fever in female rats, we injected six rats with antiserum to TNF (300 microliters/rat) and six rats with control serum 24 h before intraperitoneal injection of lipopolysaccharide (50 micrograms/kg). As occurred in earlier studies on male rats, antiserum-treated female rats had significantly enhanced fevers (P = 0.017). To determine whether endogenously produced TNF was involved in modulating the daytime and nighttime increases in BT, antiserum to TNF (300 microliters/rat, n = 7) or control serum (300 microliters/rat, n = 5) was injected intraperitoneally in exercising rats. Neither injection of antiserum nor control serum had any effect on daytime or nighttime BTs. Because BTs of exercising female rats injected with antiserum against TNF were not affected, we conclude that TNF is not responsible for modulating their exercise-induced rise in BT.