The Effect of Plethora on Erythropoietin Levels 1 2
The Effect of Plethora on Erythropoietin Levels 1 2
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过多对促红细胞生成素水平的影响 1 2
DOI：
10.3181/00379727-163-40718
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发表时间：
1980
影响因子：
--
通讯作者：
E. Cronkite
中科院分区：
文献类型：
--
作者：
Giuseppe Moccia;Marilyn E. Miller;Joseph F. Garcia;E. Cronkite
摘要 实验动物体内过量抑制红细胞生成的机制被认为与促红细胞生成素 (Ep) 水平降低有关。在 Ep 放射免疫测定 (RIA) 出现之前，由于 Ep 生物测定的不敏感性，这一理论无法得到证实。在本研究中，过度输血引起的过量输血与 CF1 小鼠血浆 Ep 水平降低约 50% 相关。感谢 Greta Duke 女士和 David Wei 先生的技术帮助。
Summary The mechanism by which plethora suppresses erythropoiesis in experimental animals has been assumed to be related to a decrease in erythropoietin (Ep) levels. Prior to the advent of a radioimmunoassay (RIA) for Ep this theory could not be confirmed because of the insensitivity of the bioassay for Ep. In the present study hypertransfusion induced plethora was associated with approximately a 50% reduction in plasma Ep levels in CF1 mice. The technical assistance of Ms. Greta Duke and Mr. David Wei is gratefully acknowledged.