Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma
Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma
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DOI：
10.1053/hupa.2002.125376
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发表时间：
2002-07-01
期刊：
影响因子：
3.3
通讯作者：
Franchi, A
中科院分区：
文献类型：
--
作者：
Gallo, O;Masini, E;Franchi, A
前列腺素通过调节包括肿瘤血管生成在内的许多生物过程，在肿瘤的发展和生长中起着关键作用，具有明确的预后和治疗意义。本研究的目的是探讨环氧化酶-2 （COX-2）通路激活在头颈部鳞状细胞癌（HNSCC）中的预后相关性。通过评估52例连续患者的蛋白表达和前列腺素E-2 （PgE(2)）水平，分析COX-2活性，并将其与血管内皮生长因子（VEGF）表达和肿瘤血管生成相关。我们通过Kaplan-Meier和Cox生存分析评估了这些参数对预后的影响。COX-2在肿瘤细胞中的表达与VEGF表达及肿瘤血管化密切相关。Kaplan-Meier分析显示，COX-2肿瘤过表达和PgE(2)肿瘤水平较高的患者总生存期估计显著缩短（P = 0.022和P = 0.033）。类似地，血管化程度较高的肿瘤患者的生存率比血管化程度较低的肿瘤患者低（P = 0.032）。Cox多因素分析显示，最重要的预后因素是淋巴结转移、肿瘤血管化、Cox -2蛋白表达和PgE(2)肿瘤水平。本研究表明COX-2通路、VEGF表达与HNSCC肿瘤血管生成密切相关。此外，COX-2过表达和较高的肿瘤血管化似乎预示着头颈癌患者的生存期较短。嗡，巡逻33:708-714。版权所有，爱思唯尔科学（美国）。版权所有。
Prostaglandins play a critical role in tumor development and growth by regulating numerous biologic processes, including tumor angiogenesis, with clear prognostic and therapeutic implications. The aim of this study was to investigate the prognostic relevance of cyclooxygenase-2 (COX-2) pathway activation in head and neck squamous cell carcinoma (HNSCC). COX-2 activity was analyzed in 52 consecutive patients by assessing protein expression and prostaglandin E-2 (PgE(2)) levels and was then correlated to vascular endothelial growth factor (VEGF) expression and tumor angiogenesis. We evaluated the prognostic impact of these parameters by Kaplan-Meier and Cox survival analysis. COX-2 expression by tumor cells was closely correlated to VEGF expression and to tumor vascularization. According to Kaplan-Meier analysis, patients with COX-2 tumor overexpression and with higher PgE(2) tumor levels had significantly shorter overall survival estimates (P = 0.022 and P = 0.033, respectively). Analogously, patients with more-vascularized tumors had worse survival than those with less-vascularized cancers (P = 0.032). Cox multivariate analysis demonstrated that the most significant prognostic factors were presence of lymph node metastasis, tumor vascularization, COX-2 protein expression, and PgE(2) tumor levels. This study demonstrates a close correlation between COX-2 pathway, VEGF expression, and tumor angiogenesis in HNSCC. In addition, COX-2 over-expression and higher tumor vascularization appear to predict a shorter survival in patients with head and neck cancer. Hum PATROL 33:708-714. Copyright 2002, Elsevier Science (USA). All rights reserved.