Role of hydrophobic interactions in collagen fibril formation: effect of alkylureas in vitro.
Role of hydrophobic interactions in collagen fibril formation: effect of alkylureas in vitro.
复制标题
疏水相互作用在胶原纤维形成中的作用：烷基脲的体外作用。
DOI：
10.1016/0003-9861(80)90125-3
复制
发表时间：
1980
影响因子：
3.9
通讯作者：
Nagel,RL
中科院分区：
文献类型：
--
作者：
Suarez,G;Veliz,M;Nagel,RL
Alkylureas inhibit the rate ofin vitrofibril formation at 10 mmrange of concentrations. There is a direct correlation between the extent of inhibition and the length of the alkyl chain (degree of hydrophobicity). When the alkylureas are added during the lag phase, the extent of inhibition depends on the time, after the onset of polymerization, in which the alkylurea is added. The effect of alkylureas is reversible since after dialysis the rate of fibril formation is normal. In conditions in which the lag phase is very short or not observable, the rate of fibril formation is not affected by the alkylureas. Ethylurea inhibits the rate of fibril formation but the extent of polymerization appears to be unaffected. In the presence of alkylurea there is an increase in the activation energy. It is concluded that hydrophobic interactions are significantly involved in the stabilization of intermediates formed during the lag phase.
