LINC00467 is up-regulated by TDG-mediated acetylation in non-small cell lung cancer and promotes tumor progression
LINC00467 is up-regulated by TDG-mediated acetylation in non-small cell lung cancer and promotes tumor progression
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LINC00467 在非小细胞肺癌中通过 TDG 介导的乙酰化上调并促进肿瘤进展
DOI：
10.1038/s41388-020-01421-w
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发表时间：
2020-08-14
期刊：
影响因子：
8
通讯作者：
Cao, Ke
中科院分区：
文献类型：
--
作者：
Zhu, Yuxing;Li, Jingjing;Cao, Ke
The long non-coding RNA (LncRNA) abnormally expresses in several cancers including non-small cell lung cancer (NSCLC). To better understand the role of key lncRNA involving cancer progress, we conduct a comprehensive data mining on LINC00467 and determine its molecular mechanisms. We identified LINC00467 was the up-regulated lncRNA that common significantly differentially expressed in NSCLC and CRC tissues from GEO database. LINC00467 highly expressed in NSCLC tissues and associated with advanced clinical stages and poor outcome. Knockdown of LINC00467 inhibited cell growth and metastasis via regulating the Akt signaling pathway. Finally, we demonstrated that TDG mediated acetylation is the key factor controlling LINC00467 expression. In conclusion, LINC00467 promotes NSCLC progression via Akt signal pathway. The identified LINC00467 may serve as a valuable diagnostic and prognostic biomarker as well as a therapeutic target for NSCLC.
