Effects of superior temporal polysensory area lesions on eye movements in the macaque monkey.
Effects of superior temporal polysensory area lesions on eye movements in the macaque monkey.
复制标题
颞上多感觉区损伤对猕猴眼球运动的影响。
DOI：
10.1152/jn.1995.73.1.1
复制
发表时间：
1995
影响因子：
2.5
通讯作者：
Gross,CG
中科院分区：
文献类型：
--
作者：
Scalaidhe,SP;Albright,TD;Rodman,HR;Gross,CG
1.根据其解剖联系和单位特性，上颞叶多感觉区(STP)似乎主要参与视觉空间功能。为了直接验证STP参与视觉空间和视觉运动行为的假设，我们研究了STP损害对眼球跳动、视觉注视和顺畅追逐眼球运动的影响。2.训练7只猴子从中央视点沿水平经络8度、15度和22度，以及从中央视点沿垂直经脉8度扫视目标。一只猴子还被训练对听觉目标进行扫视。同一批猴子接受训练，当中心注视点开始移动5度、13度或20度时，它们会凹进固定的中心视点，并跟随其平稳追逐眼球运动/S。4只猴子接受单侧STP损伤，1只猴子接受双侧STP损伤，作为对照，2只猴子接受单侧颞叶下皮质(IT)损伤。经过测试，三只单侧STP损伤的动物在第一个损伤的对侧大脑半球接受了额外的STP损伤。类似地，一只有单侧IT病变的动物在第一个病变的对侧半球接受了额外的IT病变。3.所有完全去除STP的猴子对最外围的对侧靶点的眼跳潜伏期显著延长，并且大多数猴子对其他对侧靶点的扫视潜伏期也延长。去除STP对垂直子午线上的靶点或病变同侧半视野靶点的扫视没有影响。相比之下，IT损伤并没有削弱猴子在任何位置对视觉刺激进行眼跳运动的能力，这表明对视觉引导目标的眼跳不会非特异性地受到视觉皮质损伤的损害。4.STP损伤后眼球运动的缺陷与眼跳潜伏期有关，对视觉靶点的眼跳准确性影响不大。5.在一只被训练为对听觉目标进行扫视的猴子中，移除STP并没有损害对其损害的对侧听觉目标的扫视，尽管这只猴子对视觉目标的扫视潜伏期的增加最大。6.在所有STP损伤后，眼跳潜伏期完全恢复到基线水平。(摘要截断400字)
1. On the basis of its anatomic connections and single-unit properties, the superior temporal polysensory area (STP) would seem to be primarily involved in visuospatial functions. We have examined the effects of lesions of STP on saccadic eye movements, visual fixation, and smooth pursuit eye movements to directly test the hypothesis that STP is involved in visuospatial and visuomotor behavior. 2. Seven monkeys were trained to make saccades to targets 8, 15, and 22 degrees from a central fixation point along the horizontal meridian and 8 degrees from the central fixation point along the vertical meridian. One monkey was also trained to make saccades to auditory targets. The same monkeys were trained to foveate a stationary central fixation point and to follow it with a smooth pursuit eye movement when it began moving 5, 13, or 20 degrees/s. Four monkeys received unilateral STP lesions, one received a bilateral STP lesion, and as a control, two received unilateral inferior temporal cortex (IT) lesions. After testing, three of the animals with unilateral STP lesions received an additional STP lesion in the hemisphere contralateral to the first lesion. Similarly, one animal with a unilateral IT lesion received an additional IT lesion in the hemisphere contralateral to the first lesion. 3. All monkeys with complete removal of STP showed a significant increase in saccade latency to the most peripheral contralateral target, and most also had increased saccade latencies to the other contralateral targets. Saccades directed to targets along the vertical meridian or toward targets in the hemifield ipsilateral to the lesion were not impaired by removal of STP. By contrast, IT lesions did not impair the monkeys' ability to make saccadic eye movements to visual stimuli at any location, showing that saccades to visually guided targets are not impaired nonspecifically by damage to visual cortex. 4. The deficit in making eye movements after STP lesions was specific to saccade latency, with little effect on the accuracy of saccades to visual targets. 5. In the one monkey trained to make saccades to auditory targets, removal of STP did not impair saccades to auditory targets contralateral to its lesion, despite this monkey showing the largest increase in saccades latencies to visual targets. 6. There was complete recovery of saccade latency to the baseline level of performance on the saccade task after all STP lesions.(ABSTRACT TRUNCATED AT 400 WORDS)