Indigenous hepatitis E virus infection in England: More common than it seems
Indigenous hepatitis E virus infection in England: More common than it seems
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DOI：
10.1016/j.jcv.2009.01.005
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发表时间：
2009-04-01
影响因子：
8.8
通讯作者：
Brown, David
中科院分区：
文献类型：
--
作者：
Ijaz, Samreen;Vyse, Andrew J.;Brown, David
背景：由于对戊型肝炎病毒（HEV）的认识和了解，在英国本土HEV的诊断率越来越高。然而，真正的感染负担，因此其对公共health.Objectives的影响仍然undefined：估计在一般人群中的HEV血清阳性率，并探讨如何随着时间的推移HEV感染的风险波动。研究设计：两个样本收集分层的年龄范围从1到80岁，进行了筛查HEV IgG抗体。这两次采集相隔13年，因此能够估计1991年至2004年的平均发病率。额外的力量感染calculations.Results的计算也进行了：一个整体的HEV抗体流行率为13%，确定，随着年龄的增长，在那些年龄超过50岁的峰值为25%。两个样本收集的分析表明，血清阳性率的时间转移，表明获得戊型肝炎病毒感染的风险不仅仅是年龄依赖性。数据显示，世纪中期，感染力特别高，但随后有所下降。目前的HEV发病率估计显示，发病率没有变化，在不同的年龄组。结论：这项研究表明，在英格兰的抗-HEV血清阳性率高，有一段时间的风险增加收购HEV感染，现在已经下降。发病率估计表明，在英格兰所有年龄组中，获得HEV感染的共同风险因素仍然存在。(C)2009 Elsevier B. V.保留所有权利。
Background: Indigenous hepatitis E virus (HEV) is increasingly diagnosed in England due to abetter awareness and understanding of the virus. However, the true burden of infection and therefore its implication to public health remains undefined.Objectives: To estimate the HEV seroprevalence in the general population and to investigate how the risk of HEV infection had fluctuated over time.Study design: Two sample collections stratified by age ranging from 1 to 80 years, were screened for HEV IgG antibody. The two collections were separated by 13 years enabling the average incidence between 1991 and 2004 to be estimated. Additional force of infection calculations were also undertaken.Results: An overall HEV antibody prevalence of 13% was determined, increasing with age and peaking at 25% in those aged over 50 years. Analysis of the two sample collections demonstrated a temporal shift in seroprevalence indicating that the risk of acquiring HEV infection was not solely age dependant. Data showed that the force of infection had been particularly high in the middle of the 20th century but had subsequently decreased. Current HEV incidence estimates revealed that the incidence did not vary in different age groups.Conclusions: This study indicated a high anti-HEV seroprevalence in England and that there was a period of increased risk of acquiring HEV infection which has now decreased. Incidence estimates show that shared risk factors still exist for acquiring HEV infection across all age groups in England. (C) 2009 Elsevier B.V. All rights reserved.