Hepatocyte β-catenin loss is compensated by Insulin-mTORC1 activation to promote liver regeneration.
Hepatocyte β-catenin loss is compensated by Insulin-mTORC1 activation to promote liver regeneration.
复制标题
肝细胞β-连环蛋白损失通过胰岛素-mTORC1 激活来补偿，以促进肝再生。
DOI：
10.1002/hep.32680
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Monga,SatdarshanP
中科院分区：
文献类型：
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作者：
Hu,Shikai;Cao,Catherine;Poddar,Minakshi;Delgado,Evan;Singh,Sucha;Singh-Varma,Anya;Stolz,DonnaBeer;Bell,Aaron;Monga,SatdarshanP
结论：胰岛素-mTORC 1激活补偿β-catenin损失，使PH后LR成为可能。肝细胞中的mTORC 1信号传导本身对稳态和LR都至关重要，β-catenin激活仅部分补偿。β-catenin和mTOR的双重抑制可能具有显著的不良肝毒性副作用。
Conclusions:Insulin‐mTORC1 activation compensates for β‐catenin loss to enable LR after PH. mTORC1 signaling in hepatocytes itself is critical to both homeostasis and LR and is only partially compensated by β‐catenin activation. Dual inhibition of β‐catenin and mTOR may have notable untoward hepatotoxic side effects.