STEAM-SASHA: a novel approach for blood- and fat-suppressed native T1 measurement in the right ventricular myocardium
STEAM-SASHA: a novel approach for blood- and fat-suppressed native T1 measurement in the right ventricular myocardium
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DOI：
10.1007/s10334-023-01141-8
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发表时间：
2024-01
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通讯作者：
M. Roehl;Miriam Conway;S. Ghonim;Pedro F. Ferreira;S. Nielles-Vallespin;Sonya V. Babu-Narayan;D. Pennell;Peter Gatehouse;Andrew D Scott
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作者：
M. Roehl;Miriam Conway;S. Ghonim;Pedro F. Ferreira;S. Nielles-Vallespin;Sonya V. Babu-Narayan;D. Pennell;Peter Gatehouse;Andrew D Scott
STIMULATED ECONOMY CAPACITIES MODE（STEAM）的卓越的血液和脂肪抑制可以与饱和恢复单次激发采集（SASHA）结合在一种新颖的STEAM-SASHA序列中用于右心室（RV）原生T1 mapping.Materials and methodsSTEAM-SASHA将磁化准备分为两个心动周期，使血液信号归零并允许脂肪信号衰减。屏气T1标测在T1体模中进行，10名志愿者使用STEAM-SASHA和改良的Look-T1序列在3 T收缩峰值时进行两次。结果在体模中，MOLLI低估T1，而STEAM SASHA高估T1，平均分别为3.0%和7.0%，但在典型的3 T心肌T1（T1 > 1200 ms）时，STEAM SASHA更准确。在志愿者中，STEAM-SASHA在LV和间隔中的T1高于MOLLI（分别为p= 0.03，p = 0.006），但在RV区域中较低（p> 0.05）。所有地区的研究间、观察者间和观察者内变异系数均<15%。STEAM-SASHA的血液抑制效果非常好，本底噪声影响最小。DiscussionSTEAM-SASHA在RV中提供了准确且可重复的T1，具有出色的血液和脂肪抑制。STEAM-SASHA有可能在未来的研究中为RV的病理变化提供新的见解。
ObjectiveThe excellent blood and fat suppression of stimulated echo acquisition mode (STEAM) can be combined with saturation recovery single-shot acquisition (SASHA) in a novel STEAM-SASHA sequence for right ventricular (RV) native T1 mapping.Materials and methodsSTEAM-SASHA splits magnetization preparation over two cardiac cycles, nulling blood signal and allowing fat signal to decay. Breath-hold T1 mapping was performed in a T1 phantom and twice in 10 volunteers using STEAM-SASHA and a modified Look-Locker sequence at peak systole at 3T. T1 was measured in 3 RV regions, the septum and left ventricle (LV).ResultsIn phantoms, MOLLI under-estimated while STEAM-SASHA over-estimated T1, on average by 3.0% and 7.0% respectively, although at typical 3T myocardial T1 (T1 > 1200 ms) STEAM-SASHA was more accurate. In volunteers, T1 was higher using STEAM-SASHA than MOLLI in the LV and septum (p= 0.03,p= 0.006, respectively), but lower in RV regions (p> 0.05). Inter-study, inter-observer and intra-observer coefficients of variation in all regions were < 15%. Blood suppression was excellent with STEAM-SASHA and noise floor effects were minimal.DiscussionSTEAM-SASHA provides accurate and reproducible T1 in the RV with excellent blood and fat suppression. STEAM-SASHA has potential to provide new insights into pathological changes in the RV in future studies.