Reciprocal midbrain-extended amygdala circuit activity in preclinical models of alcohol use and misuse.
Reciprocal midbrain-extended amygdala circuit activity in preclinical models of alcohol use and misuse.
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DOI：
10.1016/j.neuropharm.2021.108856
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发表时间：
2022-01-01
影响因子：
4.7
通讯作者：
Gilpin NW
中科院分区：
文献类型：
--
作者：
Avegno EM;Gilpin NW
Alcohol dependence is characterized by a shift in motivation to consume alcohol from positive reinforcement (i.e., increased likelihood of future alcohol drinking based on its rewarding effects) to negative reinforcement (i.e., increased likelihood of future alcohol drinking based on alcohol-induced reductions in negative affective symptoms, including but not limited to those experienced during alcohol withdrawal). The neural adaptations that occur during this transition are not entirely understood. Mesolimbic reinforcement circuitry (i.e., ventral tegmental area [VTA] neurons) is activated during early stages of alcohol use, and may be involved in the recruitment of brain stress circuitry (i.e., extended amygdala) during the transition to alcohol dependence, after chronic periods of high-dose alcohol exposure. Here, we review the literature regarding the role of canonical brain reinforcement (VTA) and brain stress (extended amygdala) systems, and the connections between them, in acute, sub-chronic, and chronic alcohol response. Particular emphasis is placed on preclinical models of alcohol use.
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影响因子：
16.2
作者：
Chuhma N;Mingote S;Moore H;Rayport S
通讯作者：
Rayport S
DOI：
10.1111/acer.12825
发表时间：
2015-09
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Albrechet-Souza L;Hwa LS;Han X;Zhang EY;DeBold JF;Miczek KA
通讯作者：
Miczek KA
影响因子：
16.2
作者：
Duvarci S;Pare D
通讯作者：
Pare D
影响因子：
16.6
作者：
de Guglielmo, Giordano;Kallupi, Marsida;George, Olivier
通讯作者：
George, Olivier
影响因子：
4.7
作者：
Aroni S;Marino RAM;Girven KS;Irving JM;Cheer JF;Sparta DR
通讯作者：
Sparta DR