Anterior hypothalamic neural activation and neurochemical associations with aggression in pair-bonded male prairie voles
Anterior hypothalamic neural activation and neurochemical associations with aggression in pair-bonded male prairie voles
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DOI：
10.1002/cne.21364
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发表时间：
2007-06-20
影响因子：
2.5
通讯作者：
Wang, Zuoxin
中科院分区：
文献类型：
--
作者：
Gobrogge, Kyle L.;Liu, Yan;Wang, Zuoxin
雄性草原田鼠(Microtus Ochrogaster)表现出交配诱导的配对结合，表现为与雌性伴侣的社会联系和对陌生同类的攻击性。在目前的研究中，我们描述了它们与配对结合相关的攻击行为，并检测了相关的神经元激活和神经化学结构。结对两周的男性对女性或男性同种陌生人表现出强烈的攻击性，但与他们熟悉的女性伴侣保持着高度的社会联系。这些社会互动导致了神经激活的增加，表现为终纹床核(BNST)、内侧视前区(MPOA)、室旁核(PVN)、前皮质(ACA)和杏仁内侧核(MeA)等几个脑区Fos免疫反应阳性染色密度的增加。在下丘脑前部，Fos-ir染色密度的增加被发现与攻击陌生的女性或男性陌生人有关。此外，与表现出对女性伴侣的社会联系的男性相比，这些对同种陌生人表现出攻击性的男性中，被酪氨酸羟化酶(TH)或加压素(AVP)染色的AH细胞的密度也更高。综上所述，我们的结果表明，AH中的多巴胺和加压素可能参与了雄性草原田鼠与配对结合相关的持久攻击的调节。
Male prairie voles (Microtus ochrogaster) display mating-induced pair bonding indicated by social affiliation with their female partners and aggression toward unfamiliar conspecifics. In the present study, we characterized their aggression associated with pair bonding and examined the related neuronal activation and neurochemical architecture. Males that were pair-bonded for 2 weeks displayed intense levels of aggression toward a female or male conspecific stranger but maintained a high level of social affiliation with their familiar female partners. These social interactions induced increases in neural activation, indicated by increased density of Fos-immunoreactive staining (Fos-ir) in several brain regions including the bed nucleus of the stria terminalis (BNST), medial preoptic area (MPOA), paraventricular nucleus (PVN), anterior cortical (AcA), and medial nuclei (MeA) of the amygdala. In the anterior hypothalamus (AH), increased density of Fos-ir staining was found specifically to be associated with aggression toward unfamiliar female or male strangers. In addition, higher densities of AH cells that were stained for tyrosine hydroxylase (TH) or vasopressin (AVP) were also labeled with Fos-ir in these males displaying aggression toward a conspecific stranger compared with males displaying social affiliation toward their female partner. Together, our results indicate that dopamine and vasopressin in the AH may be involved in the regulation of enduring aggression associated with pair bonding in male prairie voles.