NOD-like receptor X1, tumor necrosis factor receptor-associated factor 6 and NF-κB are associated with clinicopathological characteristics in gastric cancer
NOD-like receptor X1, tumor necrosis factor receptor-associated factor 6 and NF-κB are associated with clinicopathological characteristics in gastric cancer
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DOI：
10.3892/etm.2021.9640
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发表时间：
2021-03-01
影响因子：
2.7
通讯作者：
Zhang, Yewei
中科院分区：
文献类型：
--
作者：
Fan, Zhe;Pan, Jiyong;Zhang, Yewei
胃癌是一种常见的恶性肿瘤，其确切的发病机制尚不清楚。本研究旨在检测胃癌组织和正常胃组织中NOD样受体X1（NLRX 1）、肿瘤坏死因子受体相关因子6（TRAF 6）和NF-κ B（B）的表达水平，探讨其与胃癌临床病理特征的关系。采用免疫组化和蛋白质印迹法对60例胃癌及癌旁正常胃组织进行分析。此外，通过斯皮尔曼相关分析来研究NLRX 1、TRAF 6与NF-κ B表达水平之间的关联。结果显示，NLRX 1蛋白在胃癌组织中的表达水平较正常胃组织明显下调（P
Gastric cancer (GC) is a common cancer worldwide and its precise mechanism is largely unknown. The aim of the present study was to evaluate the expression levels of NOD-like receptor X1 (NLRX1), tumor necrosis factor receptor-associated factor 6 (TRAF6) and NF-kappa B in GC and normal gastric tissue samples to determine the association with the clinicopathological features of GC. GC and adjacent normal gastric tissues from 60 patients with GC were analyzed using immunohistochemistry and western blotting analysis. In addition, the association between NLRX1, TRAF6 and NF-kappa B expression levels were investigated by Spearman's correlation analysis. The results revealed that NLRX1 protein expression levels were downregulated in the GC tissues compared with the normal gastric tissues (P