Targeting of marrow-derived astrocytes to the ischemic brain
Targeting of marrow-derived astrocytes to the ischemic brain
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DOI：
10.1097/00001756-199904260-00025
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发表时间：
1999-04-26
期刊：
影响因子：
1.7
通讯作者：
Mouradian, MM
中科院分区：
文献类型：
--
作者：
Eglitis, MA;Dawson, D;Mouradian, MM
BONE marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.
