The role of renal biopsy in women with kidney disease identified in pregnancy
The role of renal biopsy in women with kidney disease identified in pregnancy
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DOI：
10.1093/ndt/gfm572
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发表时间：
2008-01-01
影响因子：
6.1
通讯作者：
Lipkin, Graham
中科院分区：
文献类型：
--
作者：
Day, Clara;Hewins, Peter;Lipkin, Graham
背景。肾脏疾病可能在怀孕期间首次出现，作为症状性疾病或作为产前筛查的结果。探讨产前和产后经皮肾活检在治疗此类患者中的作用。我们描述了两个系列的女性；第一个研究包括20名患有严重肾脏疾病的妇女，她们在怀孕期间需要进行肾脏活检；第二个研究包括75名妇女，她们在怀孕期间最初出现肾脏疾病，并在产后进行了肾脏活检。妊娠期间活检显示19/20（95%）肾小球疾病，9/20立即改变治疗方法（40%）。在17/20（85%）中位妊娠36周（范围25-40周）分娩一名活婴。随访妇女[中位103.3个月（2.5-256）]显示9/20（45%）的GFR为
Background. Renal disease may present for the first time in pregnancy, either as symptomatic disease or as a consequence of antenatal screening. The role of antenatal and post-partum percutaneous renal biopsy in the management of such patients is discussed.Methods. We describe two series of women; the first is a series of 20 women presenting with renal disease of a severity to warrant renal biopsy during pregnancy whilst the second, comprises 75 women who had an initial presentation of renal disease in pregnancy and underwent post-partum renal biopsy.Results. Biopsy during pregnancy revealed a glomerular disorder in 19/20 (95%) with immediate change of management in 9/20 (40%). In 17/20 (85%) there was delivery of a live infant at median gestation of 36 weeks (range 25-40). Follow-up of women [median 103.3 months (2.5-256)] showed 9/20 (45%) had a GFR of