Obesity and immunocompetence
Obesity and immunocompetence
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DOI：
10.1038/sj.ejcn.1601484
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发表时间：
2002-08-01
影响因子：
4.7
通讯作者：
Martínez, JA
中科院分区：
文献类型：
--
作者：
Lamas, O;Marti, A;Martínez, JA
肥胖症在世界范围内的日益流行是一个主要的健康问题，因为体重过重构成了许多慢性疾病的风险因素。据报道，肥胖的人比瘦的人更容易感染;然而，潜在的因素并不完全清楚。有限的和经常有争议的信息存在比较肥胖和非肥胖受试者的免疫能力，以及所涉及的细胞和分子机制，虽然很多证据支持脂肪组织代谢和免疫细胞功能之间的联系。营养状况和免疫系统相互作用的复杂性和异质性需要对免疫活性细胞、其亚群和产物以及人类肥胖情况下的特异性和非特异性诱导物/调节系统进行综合研究。需要进一步的研究来确定这些变化对免疫力的临床影响，以及减肥、运动或营养补充等各种干预措施是否有助于改善这些变化。
The increasing worldwide prevalence of obesity is a major health problem since excessive body weight constitutes a risk factor in a number of chronic diseases. It has been reported that obese individuals are more susceptible to infection than lean subjects; however, the underlying factors are not fully understood. Limited and often controversial information exists comparing immunocompetence in obese and nonobese subjects as well as the cellular and molecular mechanisms involved, although much evidence supports a link between adipose tissue metabolism and immunocompetent cell functions. The complexity and heterogeneity of nutritional status and immune system interactions require an integral study of the immunocompetent cells, their subsets and products, as well as specific and non-specific inducer/regulatory systems in situations of human obesity. Additional research is needed to determine the clinical implications of these alterations on immunity and whether various interventions such as weight loss, exercise or nutrient supplementation could help to ameliorate them.