To sleep or not to sleep: neuronal and ecological insights.

To sleep or not to sleep: neuronal and ecological insights.
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DOI:
10.1016/j.conb.2017.04.010
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发表时间:
2017-06
影响因子:
5.7
通讯作者:
de Lecea L
de Lecea L
中科院分区:
医学2区
文献类型:
--
作者:
Eban-Rothschild A;Giardino WJ;de Lecea L

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每天,动物都需要决定何时停止对环境的认知过程和行为反应,然后睡觉。调节睡眠和觉醒的日常组织的主要过程是昼夜节律和稳态睡眠压力。此外,诸如寻找食物和逃避捕食者等动机过程可以调节睡眠/觉醒行为。在这里,我们讨论了调节保持清醒或入睡倾向的主要过程,重点是神经元和行为方面。我们首先介绍参与睡眠/觉醒调节的神经元群体。接下来,我们描述睡眠的昼夜节律和自我平衡驱动。然后,我们强调的研究表明,各种影响的动机过程对睡眠/觉醒行为,并讨论可能的神经机制,其控制。
Daily, animals need to decide when to stop engaging in cognitive processes and behavioral responses to the environment, and go to sleep. The main processes regulating the daily organization of sleep and wakefulness are circadian rhythms and homeostatic sleep pressure. In addition, motivational processes such as food seeking and predator evasion can modulate sleep/wake behaviors. Here, we discuss the principal processes regulating the propensity to stay awake or go to sleep—focusing on neuronal and behavioral aspects. We first introduce the neuronal populations involved in sleep/wake regulation. Next, we describe the circadian and homeostatic drives for sleep. Then, we highlight studies demonstrating various effects of motivational processes on sleep/wake behaviors, and discuss possible neuronal mechanisms underlying their control.
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