X-ray Tomographic imaging of Tensile Deformation Modes of electrospun Biodegradable Polyester Fibers
X-ray Tomographic imaging of Tensile Deformation Modes of electrospun Biodegradable Polyester Fibers
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DOI：
10.3389/fmats.2017.00043
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发表时间：
2017-12-21
影响因子：
3.2
通讯作者：
Poologasundarampillai, Gowsihan
中科院分区：
文献类型：
--
作者：
Maksimcuka, Jekaterina;Obata, Akiko;Poologasundarampillai, Gowsihan
静电纺丝可以生产纤维网络，用于组织工程、药物输送和医疗保健中的伤口愈合。它能够生产具有大表面积和纤维形态的结构，与许多组织的细胞外基质非常相似。纤维结构不仅可以促进细胞附着和组织形成，还可以产生非常有趣的机械性能。聚（3-羟基丁酸-co-4-羟基丁酸）（P(3HB-co-4HB)）是一种可生物降解的聚酯，在失效前具有较大的延伸率（> 400%）。在这项研究中，同步加速器x射线相衬成像在P（3HB-co-4HB）纤维的无纺布纤维垫上进行拉伸变形至失效。观察到纤维在拉伸方向上的显著重定向，随后是局部颈缩和最终的破坏。由原始平均纤维直径4.3 μ m，拉伸变形后形成纤维直径的双峰分布（模态直径1.9 μ m和3.7 μ m）。在（较厚的）纤维-纤维接触之间，纤维广泛的局部缩颈（变薄）被发现是导致纤维不均匀变薄的原因，这是一种预期的现象，但之前在3D中没有观察到。这里提出的数据不仅对组织再生有影响，而且对一般纤维材料也有影响。
Electrospinning allows the production of fibrous networks for tissue engineering, drug delivery, and wound healing in health care. It enables the production of constructs with large surface area and a fibrous morphology that closely resembles the extracellular matrix of many tissues. A fibrous structure not only promotes cell attachment and tissue formation but could also lead to very interesting mechanical properties. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P(3HB-co-4HB)) is a biodegradable polyester that exhibits a large (> 400%) elongation before failure. In this study, synchrotron X-ray phase contrast imaging was performed during tensile deformation to failure on a non-woven fiber mat of P(3HB-co-4HB) fibers. Significant reorientation of the fibers in the straining direction was observed, followed by localized necking and eventual failure. From an original average fiber diameter of 4.3 mu m, a bimodal distribution of fiber diameter (modal diameters of 1.9 and 3.7 mu m) formed after tensile deformation. Extensive localized necking (thinning) of fibers between (thicker) fiber-fiber contacts was found to be the cause for non-uniform thinning of the fibers, a phenomenon that is expected but has not been observed in 3D previously. The data presented here have implications not only in tissue regeneration but for fibrous materials in general.