Prognostic value of sarcopenia in patients with liver cirrhosis: A systematic review and meta-analysis.
Prognostic value of sarcopenia in patients with liver cirrhosis: A systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0186990
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Baik SK
中科院分区：
文献类型：
--
作者：
Kim G;Kang SH;Kim MY;Baik SK
肌肉减少症是肝硬化等慢性疾病的常见综合征。最近在不同的患者群体中描述了肌肉减少症与并发症和生存率等预后之间的关系。然而，研究结果仍然没有定论。因此，本研究的目的是系统地回顾肌肉减少症对肝硬化患者预后的影响。我们根据系统评价和荟萃分析指南的首选报告项目，对肝硬化患者肌肉减少症对预后的影响进行了系统评价（SR）和荟萃分析（MA）。在确定的312项研究中，有20项符合我们的纳入标准。大多数研究使用CT诊断肌肉减少症。2项研究使用生物电阻抗分析（BIA）， 10项研究使用骨骼肌指数（SMI）， 8项研究使用腰大肌总面积（TPA）。7项研究包括亚洲参与者，其余13项研究包括西方参与者。参与者中肌肉减少症的患病率平均为48.1%，男性患病率更高，为61.6%，而女性患病率为36%。就临床结果而言，与没有肌肉减少症的患者相比，肌肉减少症患者的生存率较低，并发症（如感染）的风险增加。人种亚组分析，亚洲人的死亡率为2.45(95%可信区间(CI) = 1.44 ~ 4.16, P = 0.001)，而西方人的死亡率为1.45 （95% CI = 1.002 ~ 2.09， P<0.05）。基于SR和MA，肌肉减少症的存在与预后不良和肝硬化并发症的发生有关，可用于风险评估。此外，与西方参与者相比，亚洲参与者与肌肉减少症相关的死亡率更高。
Sarcopenia is a common syndrome in chronic diseases such as liver cirrhosis. The association between sarcopenia and outcomes, such as complications and survival has recently been described in various patient groups. However, study results remain inconclusive. Therefore, the aim of this study was to systematically review the impact of sarcopenia on outcome in patients with cirrhosis. We conducted a systematic review (SR) and meta-analysis (MA) on the impact of sarcopenia on outcome in liver cirrhosis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Of the 312 studies identified, 20 were eligible according to our inclusion criteria. Most of the studies used CT to diagnose sarcopenia. Two studies used bioelectrical impedance analysis (BIA), 10 studies used skeletal muscle index (SMI) and 8 studies used total psoas muscle area (TPA). Seven studies included Asian participants and the remaining 13 studies included Western participants. The prevalence rate of sarcopenia among participants was mean 48.1%, and appeared more among men with a rate of 61.6% whereas the rate was 36% for women. With respect to clinical outcomes, patients with sarcopenia had poorer survival rates and an increased risk of complications such as infection compared to those without sarcopenia. According to the analysis of race subgroup, Asians had a HR 2.45 (95% confidence interval (CI) = 1.44–4.16, P = 0.001) of mortality whereas Westerners had a HR 1.45 (95% CI = 1.002–2.09, P<0.05). Based on this SR and MA, the presence of sarcopenia is related to a poor prognosis and occurrence of cirrhotic complications and could be used for risk assessment. Moreover, Asian participants had higher mortality related to sarcopenia compared to the Western participants.
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间充质干细胞治疗肝纤维化。
DOI：
10.3904/kjim.2015.30.5.580
发表时间：
2015-09
期刊：
The Korean journal of internal medicine
影响因子：
--
作者：
Eom YW;Shim KY;Baik SK
通讯作者：
Baik SK
影响因子：
3.4
作者：
Kim G;Cho YZ;Baik SK
通讯作者：
Baik SK
DOI：
10.1016/j.jamcollsurg.2010.03.039
发表时间：
2010-08
影响因子：
5.2
作者：
Englesbe, Michael J.;Patel, Shaun P.;He, Kevin;Lynch, Raymond J.;Schaubel, Douglas E.;Harbaugh, Calista;Holcombe, Sven A.;Wang, Stewart C.;Segev, Dorry L.;Sonnenday, Christopher J.
通讯作者：
Sonnenday, Christopher J.
影响因子：
4.6
作者：
DiMartini, Andrea;Cruz, Ruy J., Jr.;Fontes, Paulo
通讯作者：
Fontes, Paulo
DOI：
10.1097/meg.0000000000000274
发表时间：
2015-03-01
影响因子：
2.1
作者：
Giusto, Michela;Lattanzi, Barbara;Merli, Manuela
通讯作者：
Merli, Manuela