Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control
Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control
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DOI：
10.1378/chest.14-2457
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发表时间：
2015-12-01
期刊：
影响因子：
9.6
通讯作者：
Nirula, Ajay
中科院分区：
文献类型：
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作者：
Busse, William W.;Holgate, Stephen T.;Nirula, Ajay
背景：成人哮喘的支气管扩张剂高可逆性与独特的临床特征相关。该分析比较了高可逆性 (HR) 和低可逆性 (LR) 哮喘患者的肺功能、生物标志物概况和疾病控制。方法：对两项已完成的类似设计的临床试验的数据进行回顾性分析。根据患者对支气管扩张剂的反应，将患者分为 HR 和 LR 亚组（HR = 支气管扩张剂后 Delta FEV1 >= 20%）。在控制不佳的患者中测量了血液嗜酸性粒细胞计数、血清 IgE 水平和呼出一氧化氮浓度分数，这些生物标志物通常用于将患者分为辅助性 T (Th)-2-高表型与 Th2-低表型。
BACKGROUND: High bronchodilator reversibility in adult asthma is associated with distinct clinical characteristics. This analysis compares lung function, biomarker profiles, and disease control in patients with high reversibility (HR) and low reversibility (LR) asthma.METHODS: A retrospective analysis was performed with data from two completed clinical trials of similar design. Patients were divided into HR and LR subgroups based on their response to bronchodilators (HR = Delta FEV1 postbronchodilator >= 20%). Blood eosinophil count, serum IgE level, and fraction of exhaled nitric oxide concentration, biomarkers commonly used to stratify patients into T-helper (Th)-2-high vs Th2-low phenotypes, were measured in patients with not well controlled (1.5