Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development
Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development
复制标题
DOI：
10.1242/dev.075796
复制
发表时间：
2012-05-15
期刊：
影响因子：
4.6
通讯作者：
Yoon, Jeong Kyo
中科院分区：
文献类型：
--
作者：
Jin, Yong-Ri;Han, Xiang Hua;Yoon, Jeong Kyo
外侧和内侧鼻突以及第一鳃弓的上颌突的生长和融合是唇和初级腭发育的组成部分。Wnt 9 b突变与小鼠唇裂和腭裂有关;然而，这些缺陷的原因仍然未知。在这里，我们报告说，Wnt 9 b（-/-）小鼠表现出显着延迟的鼻和上颌突起的生长，由于减少间充质细胞的增殖，这随后导致面部突起之间的物理接触失败，导致唇腭裂。Wnt 9 b（-/-）小鼠中的这些细胞缺陷主要由受损的典型WNT/β导致的FGF家族基因表达和FGF信号传导活性降低引起。连环蛋白信号传导。我们的研究已经确定了WNT 9 B和FGF信号在嘴唇和上颌发育过程中以前未知的调控联系。
Outgrowth and fusion of the lateral and medial nasal processes and of the maxillary process of the first branchial arch are integral to lip and primary palate development. Wnt9b mutations are associated with cleft lip and cleft palate in mice; however, the cause of these defects remains unknown. Here, we report that Wnt9b(-/-) mice show significantly retarded outgrowth of the nasal and maxillary processes due to reduced proliferation of mesenchymal cells, which subsequently results in a failure of physical contact between the facial processes that leads to cleft lip and cleft palate. These cellular defects in Wnt9b(-/-) mice are mainly caused by reduced FGF family gene expression and FGF signaling activity resulting from compromised canonical WNT/beta. catenin signaling. Our study has identified a previously unknown regulatory link between WNT9B and FGF signaling during lip and upper jaw development.