Reduction in Portal Vein Blood Flow by Somatostatin
Reduction in Portal Vein Blood Flow by Somatostatin
复制标题
生长抑素减少门静脉血流量
DOI：
10.2337/diab.28.10.888
复制
发表时间：
1979
期刊：
影响因子：
7.7
通讯作者：
A. Rahim Moossa
中科院分区：
文献类型：
--
作者：
J. Jaspan;K. Polonsky;Michael Lewis;A. Rahim Moossa
静脉注射生长抑素可使狗的门静脉血流量显着减少（最多 40-55%）。这种作用起效迅速，肝动脉流量、全身血压、脉搏或中心静脉压没有明显变化。作用持续时间短，但可通过持续静脉输注维持。这些观察结果与生长抑素在调节营养平衡中的内分泌作用一致。
Intravenous somatostatin boluses produced striking diminution in portal vein blood flow in dogs (maximally 40–55%). This effect was of rapid onset, without observable changes in hepatic artery flow, systemic blood pressure, pulse or central venous pressure. The duration of action was short, but could be sustained by continuous intravenous infusion. These observations are consistent with an endocrine role of somatostatin in the regulation of nutrient balance.