Immunoglobulin-A profile in breast milk from mothers delivering full term and preterm infants
Immunoglobulin-A profile in breast milk from mothers delivering full term and preterm infants
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DOI：
10.1177/039463200702000114
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发表时间：
2007-01-01
影响因子：
3.5
通讯作者：
Restani, P.
中科院分区：
文献类型：
--
作者：
Ballabio, C.;Bertino, E.;Restani, P.
低出生体重和早产新生儿护理方面的最新进展刺激了对最佳饮食计划的研究，以提高他们的生存率和短期/长期结果。母乳中某些不能包含在人工配方奶粉中的成分可能对生存至关重要。其中，免疫球蛋白很重要，特别是分泌性免疫球蛋白A (slgA)。通过免疫印迹（一种具有高特异性和可靠性的免疫电泳技术）测量足月 (TM) 或早产 (PM) 母亲乳汁中分泌型 IgA 的浓度。两组的 IgA 浓度在早期都很高，但在哺乳第一周迅速下降。 PM 中的早期 IgA 平均浓度高于 TM 中的浓度，但由于 PM 牛奶中的变异性较高，这种差异很少达到统计学显着性。哺乳期间的这种变化反映了母乳在提供免疫因子以应对生命最初几天胃肠道对高分子量蛋白质的吸收方面的重要作用。免疫保护对于早产儿尤为重要，因此尽可能提倡用自己的母乳喂养，并严格注意收奶时间。
Recent advances in the care of low-birth-weight and preterm neonates have stimulated research into the best dietetic program to improve their survival and short/long term outcome. Some components of human milk that cannot be included in artificial formulas may he critical for survival. Of these, immunoglobulins are important, and in particular secretory immunoglobulins A (slgA). The concentration of secretory IgA was measured by immunoblotting (an immunoelectrophoretic technique having high specificity and reliability) in milk from mothers delivering at term (TM) or prematurely (PM). In both groups, IgA concentrations were high very early on but quickly decreased during the first week of lactation. The early IgA mean concentration was higher in PM than in TM but, because of high variability in PM milk, the difference rarely reached statistical significance. This variability during lactation reflects the important role of human milk in supplying immunological factors to cope with the gastrointestinal absorption of high molecular weight proteins in the first days of life. Immunological protection is particularly critical for a preterm baby, so it is important to promote feeding with its own mother's milk if possible, paying strict attention to the timing of milk collection.