Increased cortisol awakening response after completing the summer treatment program in children with ADHD.
Increased cortisol awakening response after completing the summer treatment program in children with ADHD.
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完成多动症儿童的夏季治疗计划后，皮质醇觉醒反应增加。
DOI：
10.1016/j.braindev.2017.03.001
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Yamashita Y.
中科院分区：
文献类型：
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作者：
Okabe R;Okamura H;Egami C;Tada Y;Anai C;Mukasa A;Iemura A;Nagamitsu S;Furusho J;Matsuishi T;Yamashita Y.
注意力缺陷多动障碍（ADHD）儿童的皮质醇觉醒反应（CAR）知之甚少。在这里，我们检查了CAR在40名儿童多动症和他们的母亲之前，之后立即，和4个月后，41个密集的夏季治疗计划（STP）。METHODS参与者是37名儿童42岁，7-12岁，谁完成了STP在2009年和2010年，和他们的母亲。每天唾液43皮质醇测量样本收集两次，每天在觉醒和30分钟44后，在前STP，后STP，并在后续测量期间。父母评估ADHD 45症状评分，参与者完成Kid-KINDLR 46 QOL问卷。STP前ADHD儿童的TSCAR 47较低，STP后4个月增加到对照范围。STP后，母体CAR也倾向于增加48。儿童CAR的变化往往与改善的49 ADHD注意力不集中评分（p= 0.091），身体健康（p= 0.070），和学校生活50分量表得分在Kid-KINDLR（p= 0.079）。我们的研究结果表明，52 STP可以导致HPA轴功能的改善，这反映在STP后CAR 53增加。54
OBJECTIVELittle is known about the cortisol awakening response (CAR) in children 39 with attention deficit hyperactivity disorder (ADHD). Here, we examined the CAR in 40 children with ADHD and their mothers before, immediately after, and 4 months after an 41 intensive summer treatment program (STP).METHODSParticipants were 37 children 42 aged 7–12 years who completed the STP in 2009 and 2010, and their mothers. Daily saliva 43 samples for cortisol measurement were collected twice daily at awakening and 30 min 44 afterwards at pre-STP, post-STP, and during a follow-up measurement period. ADHD 45 symptom scores were evaluated by parents, and participants completed the Kid-KINDLR 46 QOL questionnaire.RESULTSCAR was low in children with ADHD before the STP, 47 and increased to the control range 4 months after STP. Maternal CAR also tended to 48 increase after STP. Changes in the CAR in children tended to correlate with an improved 49 ADHD inattention scores (p= 0.091), physical health (p= 0.070), and school life 50 subscales scores in the Kid-KINDLR (p= 0.079).CONCLUSIONWe demonstrated that 51 STP improved the behavior and QOL of children with ADHD. Our results indicate that 52 STP could lead to improvements in HPA axis function, as reflected by increased CAR 53 after STP. 54