COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study.
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study.
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DOI：
10.1007/s15010-021-01599-5
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发表时间：
2021-10
期刊：
影响因子：
7.5
通讯作者：
ISARIC Clinical Characterisation Group
中科院分区：
文献类型：
--
作者：
ISARIC Clinical Characterisation Group
ISARIC的前瞻性跨国观察研究是Covid-19的最大的同类患者。
609名住院的实验性症状患者的国际前瞻性观察研究在2020年1月30日至8月3日之间从43个国家招募了实验室确认的Covid-19。最常见的符号。
典型的症状（69％），coug（68％）和呼吸急促（66％）是最常见的患者。对于60岁的年轻人（分别为80％，79％，69％；至少有95％的孩子。 ）。 90％）和妇女（66、66、64; 90％;对男性71、70、67; 93％; 93％，每个P <0.001）。疼痛和60多年的混乱模型在性别，年龄和国家 /地区的症状上存在显着差异。
这项国际合作使我们能够报告最大的症状数据，其中包括60岁以上的成年人。在30年以下的混乱中，常见的表现是60岁以上的成年人的非典型表现。经历典型的症状，而不是男性。
在线版本包含的补充材料可获得10.1007/S15010-021-01599-5。
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men. The online version contains supplementary material available at 10.1007/s15010-021-01599-5.
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