Corpus Callosum Integrity Relates to Improvement of Upper-Extremity Function Following Intensive Rehabilitation in Children With Unilateral Spastic Cerebral Palsy.
Corpus Callosum Integrity Relates to Improvement of Upper-Extremity Function Following Intensive Rehabilitation in Children With Unilateral Spastic Cerebral Palsy.
复制标题
胼胝体完整性与单侧痉挛性脑性瘫痪儿童强化康复后上肢功能改善有关。
DOI：
10.1177/15459683211011220
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发表时间：
2021-06
影响因子：
4.2
通讯作者：
Friel K
中科院分区：
文献类型：
--
作者：
Robert MT;Gutterman J;Ferre CL;Chin K;Brandao MB;Gordon AM;Friel K
胼胝体（CC）在上肢功能中起着重要作用。对单侧痉挛性脑瘫（USCP）儿童UE功能的影响以及强化干预后的改善仍然未知。1)检查UE功能和CC完整性之间的关系。2)检查CC完整性与强化干预后UE功能变化之间的关系。我们回顾性分析了来自两项大型试验的44名参与者（年龄9.40± 3.10岁）的临床和神经影像学数据。参与者接受90小时的手臂双手强化治疗（HABIT）或约束诱导运动治疗（CIMT）。干预前后评估单手灵活性（Jebsen-Taylor手功能测试，JTTHF）和双手性能（辅助手评估，AHA）。CC纤维束成像采用扩散张量成像（DTI）重建，并分割成三个区域（躯干，中段，压部）。Pearson相关和回归用于评估结果与DTI参数之间的关系（即，分数各向异性，流线数;平均值，径向和轴向扩散率）。两组双手操作能力均有改善（P<0.01）。CIMT组单手灵巧度明显改善（P<0.01）。基线单手灵巧性和双手操作能力与大多数CC区域的各向异性分数和流线数相关（p<0.05）。CIMT后，JTTHF的前后变化与CC的轴向和径向扩散率、压部的AHA以及CC、中段和压部的流线数呈负相关（所有p<0.05）。HABIT后，中段各向异性分数与前后AHA变化呈正相关（r= 0.417，p=0.042）。CC完整性对USCP儿童的UE功能很重要。
The corpus callosum (CC) plays an important role in upper extremity (UE) function. The impact on UE function in children with unilateral spastic cerebral palsy (USCP), and improvements following intensive interventions, remain unknown. 1) Examine the relationship between UE function and CC integrity. 2) Examine the relationship between CC integrity and changes in UE function following intensive interventions. We retrospectively analyzed clinical and neuroimaging data from a sample of convenience of 44 participants (age 9.40±3.10y) from two larger trials. Participants received 90hrs of Hand-Arm Bimanual Intensive Therapy (HABIT) or Constraint-Induced Movement Therapy (CIMT). Unimanual dexterity (Jebsen-Taylor Test of Hand Function, JTTHF) and bimanual performance (Assisting Hand Assessment, AHA) were assessed pre-post intervention. CC tractography was reconstructed with diffusion tensor imaging (DTI) and segmented into three regions (genu, midbody, splenium). Pearson correlations and regression were used to assess the relationship between outcomes and DTI parameters (i.e., fractional anisotropy, number of streamlines; mean, radial and axial diffusivity). Both groups improved in bimanual performance (p<0.01). CIMT group improved in unimanual dexterity (p<0.01). Baseline unimanual dexterity and bimanual performance correlated with fractional anisotropy and number of streamlines for most CC regions (p<0.05). Following CIMT, pre-post changes in JTTHF were negatively correlated with axial and radial diffusivity of the CC, and AHA with splenium and number of streamlines for the CC, midbody, and splenium (all p<0.05). Following HABIT, midbody fractional anisotropy was positively correlated with pre-post AHA changes (r=.417, p=0.042). CC integrity is important for UE function in children with USCP.
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影响因子：
3.7
作者：
Fling, B. W.;Seidler, R. D.
通讯作者：
Seidler, R. D.
影响因子：
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作者：
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作者：
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DOI：
10.1111/j.1469-8749.2010.03840.x
发表时间：
2011-02-01
影响因子：
3.8
作者：
Koerte, Inga;Pelavin, Paula;Heinen, Florian
通讯作者：
Heinen, Florian