Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy
Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy
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DOI：
10.1016/s0002-9394(02)02093-7
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发表时间：
2003-04-01
影响因子：
4.2
通讯作者：
Paunescu, LA
中科院分区：
文献类型：
--
作者：
Schuman, JS;Wollstein, G;Paunescu, LA
目得：评价光学相干断层扫描产生的视神经乳头（ONH）测量值之间的关系（OCT;版本2和3）和共焦扫描激光检眼镜检查（CSLO），并比较OCT和CSLO ONH测量与青光眼疾病状态之间的相关性，如通过临床评估和视野检查确定的。在一项眼科学术部门青光眼服务的前瞻性研究中，在两个不同的时期招募了159只眼（97例受试者）和77只眼（44例受试者）。所有受试者均使用CSL 0器械进行扫描。在招募的第一阶段内接受测试的受试者使用OCT版本2进行扫描，在第二阶段使用OCT版本3进行扫描。主要结果测量是自动和手动定义的OCT ONH测量之间的相关性，以及CSLO和OCT ONH测量之间的相关性，设备和青光眼疾病状态。结果：通过自动确定ONH边缘获得的ONH测量值与通过手动跟踪椎间盘边缘获得的ONH测量值之间存在高度相关性（r = .93至.98）。光学相干断层扫描和CSL 0 ONH测量高度相关。光学相干断层扫描测量的平均视盘面积明显大于平均视盘面积。由CSLO确保，所有其他磁盘大小和相关参数也是如此。发现两种器械的CSLO和OCT ONH测量值与临床诊断之间相关性的受试者操作者特征（AROC）曲线下面积相似，范围为0.47 - 0.79。结论：自动OCT ONH测量值与手动追踪椎间盘边缘获得的测量值高度相关。光学相干断层扫描和CSL 0 ONH分析高度相关，并与青光眼疾病状态具有相似的相关性。(C)2003年，Elsevier Science Inc. All rights reserved.
PURPOSE: To evaluate the relationship between optic nerve head (ONH) measurements generated by optical coherence tomography (OCT; versions 2 and 3) and confocal scanning laser ophthalmoscopy (CSLO) and to compare the association between OCT and CSLO ONH measurements with glaucoma disease status, as determined by clinical evaluation and perimetry.DESIGN: Cross-sectional study.METHODS: In a prospective study in the glaucoma service of an academic department of ophthalmology, 159 eyes (97 subjects) and 77 eyes (44 subjects) were recruited in two separate periods. All subjects were scanned with a CSLO device. Subjects tested within the first period of recruitment were scanned with OCT version 2 and in the second period with OCT version 3. The main outcome measure was the correlation between automatic and manually defined OCT ONH measure, ments and the correlation of CSLO and OCT ONH measurements between devices and with glaucoma disease status.RESULTS: A high correlation was found between ONH measurements obtained by the automatic determination of ONH margin and those obtained by manual tracing ofthe disk margin (r = .93 to.98). Optical coherence tomography and CSLO ONH measurements were highly correlated. Optical coherence tomography,measured mean disk area was significantly larger than that mea. sured by CSLO, as were all other disk size,related parameters. The areas under the receiver operator char, acteristic (AROC) curves for the associations between CSLO and OCT ONH measurements and clinical diagnosis were found to be similar and in the range of 0.47 to 0.79 for both devices. 0CONCLUSIONS: Automated OCT ONH measurements correlate highly with those obtained by manual tracing of disk margin. Optical coherence tomography and CSLO ONH analyses are highly correlated and have similar associations with glaucoma disease status. (C) 2003 by Elsevier Science Inc. All rights reserved.