INVIVO DISTRIBUTION OF HUMAN-MILK LEUKOCYTES AFTER INGESTION BY NEWBORN BABOONS
INVIVO DISTRIBUTION OF HUMAN-MILK LEUKOCYTES AFTER INGESTION BY NEWBORN BABOONS
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DOI：
10.1136/adc.64.7_spec_no.930
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发表时间：
1989-07-01
影响因子：
4.4
通讯作者：
BLEND, M
中科院分区：
文献类型：
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作者：
JAIN, L;VIDYASAGAR, D;BLEND, M
研究了经肠给药的铟羟基喹啉（111 In）标记的人乳白细胞在早产狒狒体内的分布。在72小时龄时处死动物，并检查组织样品的放射性。在管腔内容物中发现最大活性，并且在肝脏和脾脏中的活性高于在骨髓中的活性，骨髓是游离同位素通常沉积的部位。这些发现表明，一些完整的牛奶白细胞可能会从胃肠道进入新生儿循环。此外，清洗数次的胃肠组织中的高活性表明白细胞粘附于粘膜或位于壁内。我们推测，单次母乳喂养后60小时胃肠道中白细胞的存在可以提供一种重要的抗感染防御机制。
The in vivo distribution of enterally administered human milk leucocytes labelled with indium hydroxyquinoline (111In) was studied in premature baboons. The animals were killed at 72 hours of age and tissue samples examined for radioactivity. Maximum activity was found in the luminal contents, and activity in the liver and spleen was higher than in bone marrow, the site where free isotope is normally deposited. These findings suggest that some intact milk leucocytes may cross from the gastrointestinal tract into the neonatal circulation. Also the high activity in gastrointestinal tissue that had been washed several times indicates that leucocytes adhere to mucosa or lie intramurally. We speculate that the presence of leucocytes in the gastrointestinal tract 60 hours after a single breast feed can provide an important defence mechanism against infection.